Document Detail

Airway obstruction in asthmatic and healthy individuals: inspiratory and expiratory thin-section CT findings.
MedLine Citation:
PMID:  9114089     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine differences in computed tomographic (CT) findings in asthmatic and healthy individuals and to correlate the findings with severity of airway obstruction. MATERIALS AND METHODS: Thirty-nine asthmatic patients and 14 healthy subjects were prospectively evaluated with thin-section CT. Inspiratory CT scans were subjectively evaluated for presence of bronchial wall thickening, bronchial dilatation, and mosaic lung attenuation; expiratory scans were subjectively evaluated for presence of air trapping. Objective measurement of bronchoarterial-diameter ratio was performed on inspiratory scans. CT findings were compared with pulmonary function test results. RESULTS: Bronchial wall thickening, severe air trapping, and reduced bronchoarterial-diameter ratio were observed more commonly in asthmatic patients than in healthy subjects. Bronchial wall thickening was more prevalent among patients with severe airflow obstruction (10 of 12 readings [83%]) than in patients with normal airflow (15 of 40 readings [38%]) or mild obstruction (nine of 26 readings [35%]). Other subjectively determined CT findings did not correlate with pulmonary function test results. The mean bronchoarterial-diameter ratios +/- 1 standard deviation were 0.65 +/- 0.16 in healthy subjects and 0.60 +/- 0.16, 0.60 +/- 0.18, and 0.48 +/- 0.11 in patients with normal airflow and mild and severe obstruction, respectively. CONCLUSION: Thin-section CT is of limited value in distinguishing asthmatic patients with normal airflow or mild airflow obstruction from healthy subjects.
C S Park; N L Müller; S A Worthy; J S Kim; N Awadh; M Fitzgerald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  203     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-05-13     Completed Date:  1997-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  AIM; IM    
Department of Radiology, University of British Columbia and Vancouver Hospital and Health Sciences Centre, Canada.
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MeSH Terms
Airway Obstruction / radiography*
Asthma / complications,  physiopathology,  radiography*
Middle Aged
Prospective Studies
Respiration / physiology*
Respiratory Function Tests
Tomography, X-Ray Computed*

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