| Airway nitric oxide in patients with cystic fibrosis is associated with pancreatic function, Pseudomonas infection, and polyunsaturated fatty acids. | |
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MedLine Citation:
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PMID: 17400678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Airway nitric oxide (NO) is low or normal in cystic fibrosis (CF) patients. This may affect bacterial status since NO has antimicrobial properties. Arachidonic acid (AA), which is increased in the serum and airways of CF patients, has been shown to reduce NO levels. The aim of this study was to investigate whether airway NO level correlates with genotype and pancreatic function, and whether low airway NO level is associated with bacterial infection and increased serum AA level in CF patients. METHOD: Nasal NO (nNO) and exhaled NO (eNO) were measured according to the European Respiratory Society/American Thoracic Society standard in 59 CF patients aged 7 to 55 years, 80% of whom were pancreatic insufficient (PI) and 51% were chronically infected with Pseudomonas aeruginosa. RESULTS: PI CF patients had significantly lower nNO levels than pancreatic-sufficient (PS) patients. Airway NO level did not correlate with lung function or inflammatory parameters. PI patients chronically infected with P aeruginosa had significantly lower nNO levels than noninfected PI patients. nNO level correlated inversely with the AA/docosahexaenoic acid ratio, and eNO with the essential fatty acid (FA) deficiency index, which is the ratio between mead acid and AA. CONCLUSIONS: CF patients with PI, which is associated with more severe genotypes, had lower airway NO levels than patients with PS. Low NO level was correlated to chronic P aeruginosa infection, and an association was found between airway NO level and the abnormal serum phospholipid FA pattern. |
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Authors:
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Christina Keen; Anna-Carin Olin; Asa Edentoft; Eva Gronowitz; Birgitta Strandvik |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-30 |
Journal Detail:
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Title: Chest Volume: 131 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-13 Completed Date: 2007-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1857-64 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Sahlgrenska Academy, Göteborg, Sweden. Christina.keen@vgregion.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arachidonic Acid / blood Breath Tests Child Cystic Fibrosis / complications, genetics, metabolism* Cystic Fibrosis Transmembrane Conductance Regulator / genetics, metabolism Exocrine Pancreatic Insufficiency / metabolism* Fatty Acids, Essential / blood Fatty Acids, Unsaturated / blood* Female Genotype Humans Male Middle Aged Nasal Cavity / chemistry Nitric Oxide / analysis*, metabolism Pseudomonas Infections / metabolism* Pseudomonas aeruginosa / pathogenicity |
| Chemical | |
Reg. No./Substance:
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0/CFTR protein, human; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 10102-43-9/Nitric Oxide; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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