Document Detail

Airway nitric oxide in patients with cystic fibrosis is associated with pancreatic function, Pseudomonas infection, and polyunsaturated fatty acids.
MedLine Citation:
PMID:  17400678     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Airway nitric oxide (NO) is low or normal in cystic fibrosis (CF) patients. This may affect bacterial status since NO has antimicrobial properties. Arachidonic acid (AA), which is increased in the serum and airways of CF patients, has been shown to reduce NO levels. The aim of this study was to investigate whether airway NO level correlates with genotype and pancreatic function, and whether low airway NO level is associated with bacterial infection and increased serum AA level in CF patients. METHOD: Nasal NO (nNO) and exhaled NO (eNO) were measured according to the European Respiratory Society/American Thoracic Society standard in 59 CF patients aged 7 to 55 years, 80% of whom were pancreatic insufficient (PI) and 51% were chronically infected with Pseudomonas aeruginosa. RESULTS: PI CF patients had significantly lower nNO levels than pancreatic-sufficient (PS) patients. Airway NO level did not correlate with lung function or inflammatory parameters. PI patients chronically infected with P aeruginosa had significantly lower nNO levels than noninfected PI patients. nNO level correlated inversely with the AA/docosahexaenoic acid ratio, and eNO with the essential fatty acid (FA) deficiency index, which is the ratio between mead acid and AA. CONCLUSIONS: CF patients with PI, which is associated with more severe genotypes, had lower airway NO levels than patients with PS. Low NO level was correlated to chronic P aeruginosa infection, and an association was found between airway NO level and the abnormal serum phospholipid FA pattern.
Christina Keen; Anna-Carin Olin; Asa Edentoft; Eva Gronowitz; Birgitta Strandvik
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-30
Journal Detail:
Title:  Chest     Volume:  131     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1857-64     Citation Subset:  AIM; IM    
Department of Pediatrics, Sahlgrenska Academy, Göteborg, Sweden.
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MeSH Terms
Arachidonic Acid / blood
Breath Tests
Cystic Fibrosis / complications,  genetics,  metabolism*
Cystic Fibrosis Transmembrane Conductance Regulator / genetics,  metabolism
Exocrine Pancreatic Insufficiency / metabolism*
Fatty Acids, Essential / blood
Fatty Acids, Unsaturated / blood*
Middle Aged
Nasal Cavity / chemistry
Nitric Oxide / analysis*,  metabolism
Pseudomonas Infections / metabolism*
Pseudomonas aeruginosa / pathogenicity
Reg. No./Substance:
0/CFTR protein, human; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 10102-43-9/Nitric Oxide; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 506-32-1/Arachidonic Acid

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