| Airway narrowing in porcine bronchi with and without lung parenchyma. | |
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MedLine Citation:
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PMID: 16264040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During bronchoconstriction elastic after-loads arise due to distortion of lung parenchyma by the narrowing airway. In the present study, the functional effect of parenchymal elastic after-load on airway narrowing was determined. Airway narrowing was measured in vivo over a range of transpulmonary pressures and compared with in vitro narrowing measured at corresponding transmural pressures. Bronchi were generation 10 with internal diameters of approximately 4 mm. In vivo luminal narrowing was measured by videobronchoscopy in anaesthetised and ventilated pigs. In vitro luminal narrowing was measured by videoendoscopy in isolated bronchial segments. Airways were activated by maximum vagal nerve stimulation and maximum electrical field stimulation in vivo and in vitro, respectively. At 5 cmH2O, stimulation produced a 35.9+/-3.2% (n = 6) and a 36.5+/-2.4% (n = 11) decrease in lumen diameter in vivo and in vitro, respectively. At 30 cmH2O, luminal narrowing fell to 23.7+/-2.0% in vivo and 23.4+/-2.5% in vitro. There was no difference between luminal narrowing in vivo and in vitro at any pressure. In conclusion, these findings suggest that in mid-sized, cartilaginous bronchi, parenchymal elastic after-loads do not restrict airway narrowing. |
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Authors:
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P B Noble; A Sharma; P K McFawn; H W Mitchell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 26 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-02 Completed Date: 2006-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 804-11 Citation Subset: IM |
Affiliation:
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Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia. noblep01@cyllene.uwa.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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physiology* Animals Bronchi / anatomy & histology*, physiology* Bronchoconstriction / physiology* Elasticity Female Humans Stress, Mechanical Swine Work of Breathing |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2005 Nov;26(5):759-61
[PMID:
16264032
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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