Document Detail

Airway mucosal inflammation even in patients with newly diagnosed asthma.
MedLine Citation:
PMID:  8442607     Owner:  NLM     Status:  MEDLINE    
We have studied bronchial biopsies from 14 patients with newly diagnosed asthma (four men and 10 women), who had had asthma symptoms, on average, 7.4 months (range, 2 to 12 months) and from four control subjects. The patients had not received corticosteroids, disodium cromoglycate, or theophylline before the study. The bronchial biopsies were taken, using a rigid-tube bronchoscope under local anaesthesia, from two different airway levels: (1) inside the right upper lobe bronchus, and (2) at the opening of the right middle lobe. The specimens were prepared for both light and electron microscopy. The use of Slot grids 1 x 2 mm enabled a large area of the thin sections to be photographed and analyzed by applying a graphic Autocad program. There was an increase in the numbers of mast cells (p < 0.001), eosinophils (p < 0.05), lymphocytes (p < 0.05), and macrophages (p < 0.05) in the epithelium of patients with newly diagnosed asthma as compared with those in control subjects. In the lamina propria, these asthmatic patients had more eosinophils (p < 0.001), lymphocytes (p < 0.001), macrophages (p < 0.001), and plasma cells (p < 0.001) than did the control subjects. We conclude that, in asthma, an airway inflammatory process is present even at a clinically early stage of the disease. In the asthmatic airways, there are signs of a general inflammatory response caused by more than one cell type.
L A Laitinen; A Laitinen; T Haahtela
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  147     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-01     Completed Date:  1993-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  697-704     Citation Subset:  AIM; IM    
Department of Pulmonary Medicine, University Central Hospital, Helsinki, Finland.
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MeSH Terms
Asthma / pathology*
Bronchi / ultrastructure*
Bronchial Provocation Tests
Bronchitis / pathology*
Dose-Response Relationship, Drug
Epithelium / ultrastructure
Histamine / diagnostic use
Microscopy, Electron
Middle Aged
Mucous Membrane / ultrastructure
Reg. No./Substance:

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