| Airway mucosal inflammation even in patients with newly diagnosed asthma. | |
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MedLine Citation:
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PMID: 8442607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied bronchial biopsies from 14 patients with newly diagnosed asthma (four men and 10 women), who had had asthma symptoms, on average, 7.4 months (range, 2 to 12 months) and from four control subjects. The patients had not received corticosteroids, disodium cromoglycate, or theophylline before the study. The bronchial biopsies were taken, using a rigid-tube bronchoscope under local anaesthesia, from two different airway levels: (1) inside the right upper lobe bronchus, and (2) at the opening of the right middle lobe. The specimens were prepared for both light and electron microscopy. The use of Slot grids 1 x 2 mm enabled a large area of the thin sections to be photographed and analyzed by applying a graphic Autocad program. There was an increase in the numbers of mast cells (p < 0.001), eosinophils (p < 0.05), lymphocytes (p < 0.05), and macrophages (p < 0.05) in the epithelium of patients with newly diagnosed asthma as compared with those in control subjects. In the lamina propria, these asthmatic patients had more eosinophils (p < 0.001), lymphocytes (p < 0.001), macrophages (p < 0.001), and plasma cells (p < 0.001) than did the control subjects. We conclude that, in asthma, an airway inflammatory process is present even at a clinically early stage of the disease. In the asthmatic airways, there are signs of a general inflammatory response caused by more than one cell type. |
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Authors:
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L A Laitinen; A Laitinen; T Haahtela |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American review of respiratory disease Volume: 147 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-04-01 Completed Date: 1993-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 697-704 Citation Subset: AIM; IM |
Affiliation:
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Department of Pulmonary Medicine, University Central Hospital, Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / pathology* Biopsy Bronchi / ultrastructure* Bronchial Provocation Tests Bronchitis / pathology* Bronchoscopy Dose-Response Relationship, Drug Epithelium / ultrastructure Female Histamine / diagnostic use Humans Male Microscopy, Electron Middle Aged Mucous Membrane / ultrastructure |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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