Document Detail


Airway monitoring by collection and mass spectrometric analysis of exhaled particles.
MedLine Citation:
PMID:  19140778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a new method for simultaneously collecting particles in exhaled air for subsequent chemical analysis and measuring their size distribution. After forced exhalation, particles were counted and collected in spots on silicon wafers with a cascade impactor. Several phospholipids were identified by time-of-flight secondary ion mass spectrometric analysis of the collected spots, suggesting that the particles originated from the lower airways. The amount of particles collected in ten exhalations was sufficient for characterizing the phospholipid composition. The feasibility of the technique in respiratory research is demonstrated by analysis of the phospholipid composition of exhaled particles from healthy controls, patients with asthma, and patients with cystic fibrosis. We believe this technology will be useful for monitoring patients with respiratory disease and has a high potential to detect new biomarkers in exhaled air.
Authors:
Ann-Charlotte Almstrand; Evert Ljungström; Jukka Lausmaa; Björn Bake; Peter Sjövall; Anna-Carin Olin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Analytical chemistry     Volume:  81     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  662-8     Citation Subset:  IM    
Affiliation:
Occupational and Environmental Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / diagnosis
Biological Markers / analysis
Breath Tests / methods*
Cystic Fibrosis / diagnosis
Exhalation
Female
Humans
Male
Mass Spectrometry / methods
Middle Aged
Monitoring, Physiologic
Phospholipids / analysis*
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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