Document Detail

Airway ion transport on the first postnatal day in infants delivered vaginally or by elective cesarean section.
MedLine Citation:
PMID:  12700365     Owner:  NLM     Status:  MEDLINE    
To determine airway ion transport in term infants on the first day of postnatal life, and to test the hypothesis that infants born without labor have reduced sodium absorption, we measured nasal potential difference using a modified perfusion protocol suitable for newborn infants. We examined maximal stable baseline potential difference, the change after perfusion with 10(-4) M amiloride (Deltaamil), and the change after perfusion with a zero-chloride solution (Deltazero Cl-) in infants born after elective cesarean section (n = 21) or normal labor (n = 20). Maximal stable baseline potential difference was not different in the two cohorts (-24.0 mV, range -9 to -64 mV versus -25.5 mV, range -6 to -44 mV). The majority of infants in both cohorts showed a substantial fall in potential difference after amiloride perfusion, and there was little capacity for chloride secretion. These results demonstrate a fluid absorptive pattern in the airways on the first postnatal day. In these well infants, the ion transport phenotype was not dependent on the presence or absence of labor.
Erol A Gaillard; Nigel J Shaw; Helen L Wallace; Nimish V Subhedar; Kevin W Southern
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-04-16
Journal Detail:
Title:  Pediatric research     Volume:  54     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  IM    
Liverpool Women's Hospital, Neonatal Unit, University of Liverpool, Liverpool, UK.
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MeSH Terms
Cesarean Section*
Chlorides / metabolism*
Epithelial Sodium Channel
Infant, Newborn
Nose / metabolism
Sodium / metabolism*
Sodium Channels / metabolism
Reg. No./Substance:
0/Chlorides; 0/Epithelial Sodium Channel; 0/Sodium Channels; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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