Document Detail

Airway inflammation after controlled exposure to diesel exhaust particulates.
MedLine Citation:
PMID:  10903236     Owner:  NLM     Status:  MEDLINE    
Epidemiologic evidence suggests a link between morbidity and mortality and levels of particulate matter in the atmosphere. We studied the inflammatory response to inhalation of diesel exhaust particulates (DEP) in normal volunteers. DEP were collected from the exhaust of a stationary diesel engine and were resuspended in an exposure chamber. Ten nonsmoking healthy volunteers were exposed for 2 h at rest to a controlled concentration of DEP (monitored at 200 microg/m(3) particulate matter of less than 10 microm aerodynamic diameter [PM(10)]) or air in a double-blind, randomized, crossover study. Exposures were followed by serial spirometry and measurement of pulse, blood pressure, exhaled carbon monoxide (CO), and methacholine reactivity, as well as sputum induction and venesection for up to 4 h after exposure, and a repeat of all these procedures at 24 h after exposure. There were no changes in cardiovascular parameters or lung function following exposure to DEP. Levels of exhaled CO were increased ater exposure to DEP, and were maximal at 1 h (air: 2.9 +/- 0.2 ppm [mean +/- SEM]; DEP: 4.4 +/- 0.3 ppm; p < 0.001). There was an increase in sputum neutrophils and myeloperoxidase (MPO) at 4 h after DEP exposure as compared with 4 h after air exposure (neutrophils: 41 +/- 4% versus 32 +/- 4%; MPO: 151 ng/ml versus 115 ng/ml, p < 0.01), but no change in concentrations of inflammatory markers in peripheral blood. Exposure to DEPs at high ambient concentrations leads to an airway inflammatory response in normal volunteers.
J A Nightingale; R Maggs; P Cullinan; L E Donnelly; D F Rogers; R Kinnersley; K F Chung; P J Barnes; M Ashmore; A Newman-Taylor
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  162     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-13     Completed Date:  2000-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  AIM; IM    
Departments of Thoracic Medicine and Occupational and Environmental Medicine, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, UK.
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MeSH Terms
Double-Blind Method
Inflammation / chemically induced*
Respiratory System / drug effects*
Sputum / cytology
Vehicle Emissions / adverse effects*
Reg. No./Substance:
0/Vehicle Emissions

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