Document Detail

Airway inflammation after cessation of exposure to agents causing occupational asthma.
MedLine Citation:
PMID:  14578217     Owner:  NLM     Status:  MEDLINE    
Subjects with occupational asthma (OA) generally present asthma symptoms and airway hyperresponsiveness after cessation of exposure. We hypothesized that they are also left with airway inflammation. We assessed 133 subjects with OA at a mean interval of 8.7 years (0.5-20.8 years) after cessation of exposure by questionnaire, airway caliber, and responsiveness to methacholine. Satisfactory samples of induced sputum were obtained from 98 subjects. We defined three groups of subjects: (1) cured: normalization of the concentration of methacholine provoking a 20% decrease in FEV1 (PC20), (2) improved: increase in PC20 by 3.2-fold or more but PC20 still abnormal, and (3) not improved: no significant change in PC20. In all, 9/28 subjects (32.1%) with no improvement versus 6/56 (10.7%) subjects with partial and complete improvements had sputum eosinophils equal to or greater than 2% and 11/28 (39.3%) subjects versus 11/56 (19.6%) subjects showed sputum neutrophils equal to or greater than 61%. Levels of interleukin-8 and of the neutrophil-derived myeloperoxidase were significantly more elevated in sputum of subjects with no improvement. Those in the cured or improved groups had a significantly longer time lapse since diagnosis and a higher PC20 at the time of diagnosis. We conclude that failure to improve after cessation of exposure to an agent causing OA is associated with airway inflammation at follow-up.
Karim Maghni; Catherine Lemière; Heberto Ghezzo; Wu Yuquan; Jean-Luc Malo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-10-24
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  169     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  AIM; IM    
Department of Chest Medicine, Sacré-Coeur Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Airway Resistance / physiology
Asthma / etiology,  physiopathology*
Bronchial Provocation Tests
Cohort Studies
Follow-Up Studies
Inflammation / physiopathology
Inflammation Mediators / analysis*
Interleukin-8 / analysis
Logistic Models
Methacholine Chloride / diagnostic use
Middle Aged
Occupational Diseases / diagnosis*
Occupational Exposure / adverse effects*
Peroxidase / analysis
Respiratory Function Tests
Risk Assessment
Sampling Studies
Sputum / cytology
Time Factors
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-8; 62-51-1/Methacholine Chloride; EC
Comment In:
Am J Respir Crit Care Med. 2004 Feb 1;169(3):331-2   [PMID:  14739131 ]

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