Airway inflammation after cessation of exposure to agents causing occupational asthma.

Airway inflammation after cessation of exposure to agents causing occupational asthma.

MedLine Citation:	PMID: 14578217 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	Subjects with occupational asthma (OA) generally present asthma symptoms and airway hyperresponsiveness after cessation of exposure. We hypothesized that they are also left with airway inflammation. We assessed 133 subjects with OA at a mean interval of 8.7 years (0.5-20.8 years) after cessation of exposure by questionnaire, airway caliber, and responsiveness to methacholine. Satisfactory samples of induced sputum were obtained from 98 subjects. We defined three groups of subjects: (1) cured: normalization of the concentration of methacholine provoking a 20% decrease in FEV1 (PC20), (2) improved: increase in PC20 by 3.2-fold or more but PC20 still abnormal, and (3) not improved: no significant change in PC20. In all, 9/28 subjects (32.1%) with no improvement versus 6/56 (10.7%) subjects with partial and complete improvements had sputum eosinophils equal to or greater than 2% and 11/28 (39.3%) subjects versus 11/56 (19.6%) subjects showed sputum neutrophils equal to or greater than 61%. Levels of interleukin-8 and of the neutrophil-derived myeloperoxidase were significantly more elevated in sputum of subjects with no improvement. Those in the cured or improved groups had a significantly longer time lapse since diagnosis and a higher PC20 at the time of diagnosis. We conclude that failure to improve after cessation of exposure to an agent causing OA is associated with airway inflammation at follow-up.

Authors:	Karim Maghni; Catherine Lemière; Heberto Ghezzo; Wu Yuquan; Jean-Luc Malo
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Publication Detail:	Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2003-10-24
Journal Detail:	Title: American journal of respiratory and critical care medicine Volume: 169 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2004 Feb
Date Detail:	Created Date: 2004-01-23 Completed Date: 2004-02-26 Revised Date: 2006-11-15
Medline Journal Info:	Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States
Other Details:	Languages: eng Pagination: 367-72 Citation Subset: AIM; IM
Affiliation:	Department of Chest Medicine, Sacré-Coeur Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:	Adult Airway Resistance / physiology Asthma / etiology, physiopathology* Bronchial Provocation Tests Cohort Studies Female Follow-Up Studies Humans Inflammation / physiopathology Inflammation Mediators / analysis* Interleukin-8 / analysis Logistic Models Male Methacholine Chloride / diagnostic use Middle Aged Occupational Diseases / diagnosis* Occupational Exposure / adverse effects* Peroxidase / analysis Probability Respiratory Function Tests Risk Assessment Sampling Studies Sputum / cytology Time Factors
Chemical
Reg. No./Substance:	0/Inflammation Mediators; 0/Interleukin-8; 62-51-1/Methacholine Chloride; EC 1.11.1.7/Peroxidase
Comments/Corrections
Comment In:	Am J Respir Crit Care Med. 2004 Feb 1;169(3):331-2 [PMID: 14739131 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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