Document Detail


Airway immunopathology of asthma with exercise-induced bronchoconstriction.
MedLine Citation:
PMID:  16159628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exercise-induced bronchoconstriction (EIB) is a common cause of symptoms in a subgroup of asthmatic subjects. The pathobiology that makes this group of asthmatic subjects susceptible to bronchoconstriction after a brief period of exercise remains poorly understood.
OBJECTIVE: We sought to determine whether there are differences in lower airway inflammation and production of cytokines and eicosanoids between asthmatic subjects with and without EIB.
METHODS: Two distinct groups of asthmatic subjects based on a priori definitions were identified, one with moderate-to-severe EIB and the other without significant bronchoconstriction after exercise challenge. Both groups met the definition of asthma on the basis of bronchodilator response, bronchial hyperresponsiveness, or both. A comparative immunopathology study was conducted by using induced sputum to identify differences in lower airway inflammation and production of cytokines and eicosanoids.
RESULTS: The groups had similar baseline lung function and bronchodilator response and did not have any asthma exacerbations within the prior year. The concentration of columnar epithelial cells was markedly higher in the group with EIB (1.4 x 10(5) vs 2.9 x 10(4) cells/mL, P=.01). The concentration of eosinophils was higher in the group with EIB (3.6 x 10(4) vs 4.9 x 10(3) cells/mL P=.04). Cysteinyl leukotrienes (CysLTs; 727.7 vs 151.9 pg/mL, P=.01) and the ratio of CysLTs to prostaglandin E(2) (1.85 vs 1.04, P=.002) in the airways were higher in the group with EIB.
CONCLUSION: Injury to the airway epithelium, overexpression of CysLTs, relative under production of prostaglandin E(2), and greater airway eosinophilia are distinctive immunopathologic features of asthma with EIB.
Authors:
Teal S Hallstrand; Mark W Moody; Moira L Aitken; William R Henderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  116     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-14     Completed Date:  2005-11-15     Revised Date:  2011-06-16    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-93     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle, WA 98195, USA. tealh@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma, Exercise-Induced / immunology*,  pathology*
Cytokines / analysis,  immunology
Eicosanoids / analysis,  immunology
Eosinophils / immunology
Female
Humans
Lung / immunology*,  pathology*
Male
Middle Aged
Sputum / chemistry,  cytology,  immunology
Grant Support
ID/Acronym/Agency:
HL04231/HL/NHLBI NIH HHS; K23 HL004231-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Eicosanoids
Comments/Corrections
Erratum In:
J Allergy Clin Immunol. 2007 Aug;120(2):307
J Allergy Clin Immunol. 2008 Apr;121(4):999

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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