Document Detail

Airway hyperresponsiveness to methacholine in subjects with spinal cord injury.
MedLine Citation:
PMID:  8874244     Owner:  NLM     Status:  MEDLINE    
Previously, we found that never-smokers with quadriplegia were hyperresponsive to aerosolized methacholine. To further explore the phenomenon, we compared responsiveness to methacholine in never-smokers with that of smokers and ex-smokers. We also evaluated responsiveness in subjects with high paraplegia (lesions at T-1 to T-6) or low paraplegia (lesions at T-7 and below). We found that smokers and ex-smokers with quadriplegia were hyperresponsive to methacholine (provocative concentration causing a 20% fall in FEV1 = 1.9 mg/mL), and that the response was comparable to that found in never-smokers, revealing that hyperresponsiveness among never-smokers cannot be attributed to preinjury airway hyperreactivity that precluded cigarette use. In contrast, subjects with low paraplegia were not hyperresponsive to methacholine. Among subjects with high paraplegia, the three subjects demonstrating airway hyperresponsiveness had significantly lower FEV1 (percent predicted). The findings support the hypothesis that airway hyperresponsiveness in subjects with quadriplegia represents loss of sympathetic innervation of the lung, thereby leaving intact unopposed bronchoconstrictor cholinergic activity. However, reduced lung volumes in these subjects also suggest the possibility that airway hyperresponsiveness is due to loss of ability to stretch airway smooth muscle by deep breathing.
E Singas; M Lesser; A M Spungen; W A Bauman; P L Almenoff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  110     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-20     Completed Date:  1996-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  911-5     Citation Subset:  AIM; IM    
Pulmonary Section, Bronx (NY) Veterans Affairs Medical Center 10468, USA.
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MeSH Terms
Bronchi / drug effects*
Bronchial Hyperreactivity*
Bronchial Provocation Tests
Bronchoconstriction / physiology
Bronchoconstrictor Agents / pharmacology*
Methacholine Chloride / pharmacology*
Middle Aged
Muscle, Smooth / physiopathology
Quadriplegia / physiopathology
Smoking / physiopathology
Spinal Cord Injuries / physiopathology*
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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