| Airway hyperresponsiveness in patients with coronary spastic angina: relationship between coronary spasticity and airway responsiveness. | |
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MedLine Citation:
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PMID: 17251674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several reports have suggested a possible link between bronchial asthma and coronary spasm, but the possibility of a relationship in coronary spastic angina (CSA) has not been clarified. METHODS AND RESULTS: Airway responsiveness to methacholine and coronary spasticity to acetylcholine were examined in 42 patients with CSA and 36 patients with chest pain syndrome (CP). Furthermore, 18 control subjects were examined and their airway responsiveness compared with that of the CSA and CP patients. The incidence of airway hyperresponsiveness was significantly higher in the CSA group (74%) than in the CP (19%) and control (17%) groups (p<0.0001). The geometric mean of the log minimum dose (Dmin), defined as the cumulative dose at the point at which respiratory conductance began to decrease, was significantly lower in the CSA group (0.75 log units) than in the CP (1.20 log units) and control (1.38 log units) groups (p=0.004). CONCLUSION: These results demonstrate that acetylcholine-induced coronary spasticity is significantly related to methacholine-induced airway responsiveness in patients with CSA. A generalized hyperresponsiveness of the vascular and nonvascular smooth muscles, including that through cholinergic mechanisms, may exist in patients with CSA. |
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Authors:
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Shoji Haruta; Michiko Okayama; Tatsuro Uchida; Koshichiro Hirosawa; Hiroshi Kasanuki |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 71 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-25 Completed Date: 2007-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 234-41 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Tokyo Women's Medical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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diagnostic use Adult Aged Angina Pectoris / physiopathology* Bronchial Provocation Tests Bronchoconstrictor Agents / diagnostic use Coronary Angiography Coronary Vasospasm / physiopathology* Exercise Test Female Humans Male Methacholine Chloride / diagnostic use Middle Aged Muscle, Smooth, Vascular* / physiopathology Respiratory Hypersensitivity / physiopathology* Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 0/Vasodilator Agents; 51-84-3/Acetylcholine; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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