Document Detail

Airway hyperresponsiveness in patients with coronary spastic angina: relationship between coronary spasticity and airway responsiveness.
MedLine Citation:
PMID:  17251674     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several reports have suggested a possible link between bronchial asthma and coronary spasm, but the possibility of a relationship in coronary spastic angina (CSA) has not been clarified. METHODS AND RESULTS: Airway responsiveness to methacholine and coronary spasticity to acetylcholine were examined in 42 patients with CSA and 36 patients with chest pain syndrome (CP). Furthermore, 18 control subjects were examined and their airway responsiveness compared with that of the CSA and CP patients. The incidence of airway hyperresponsiveness was significantly higher in the CSA group (74%) than in the CP (19%) and control (17%) groups (p<0.0001). The geometric mean of the log minimum dose (Dmin), defined as the cumulative dose at the point at which respiratory conductance began to decrease, was significantly lower in the CSA group (0.75 log units) than in the CP (1.20 log units) and control (1.38 log units) groups (p=0.004). CONCLUSION: These results demonstrate that acetylcholine-induced coronary spasticity is significantly related to methacholine-induced airway responsiveness in patients with CSA. A generalized hyperresponsiveness of the vascular and nonvascular smooth muscles, including that through cholinergic mechanisms, may exist in patients with CSA.
Shoji Haruta; Michiko Okayama; Tatsuro Uchida; Koshichiro Hirosawa; Hiroshi Kasanuki
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  234-41     Citation Subset:  IM    
Department of Cardiology, Tokyo Women's Medical University, Japan.
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MeSH Terms
Acetylcholine / diagnostic use
Angina Pectoris / physiopathology*
Bronchial Provocation Tests
Bronchoconstrictor Agents / diagnostic use
Coronary Angiography
Coronary Vasospasm / physiopathology*
Exercise Test
Methacholine Chloride / diagnostic use
Middle Aged
Muscle, Smooth, Vascular* / physiopathology
Respiratory Hypersensitivity / physiopathology*
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Bronchoconstrictor Agents; 0/Vasodilator Agents; 51-84-3/Acetylcholine; 62-51-1/Methacholine Chloride

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