| Airway hyperresponsiveness: a comparative study of methacholine and exercise challenges in seasonal allergic rhinitis with or without asthma. | |
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MedLine Citation:
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PMID: 19544170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Asymptomatic airway hyperreactivity in allergic rhinitis is a risk factor for later development of asthma. Although non-specific bronchial hyperresponsiveness (BHR) has been measured by several stimuli, the most appropriate measurement technique still remains unclear. OBJECTIVE: To investigate whether an exercise challenge can be used to predict BHR in seasonal allergic rhinitis patients with or without asthma and to compare this bronchial reactivity with a methacholine challenge technique. METHODS: Forty-six consecutive patients with seasonal allergic rhinitis only (n = 31) and with both seasonal allergic rhinitis and asthma (n = 15) were included in the study during the pollination period. Subjects underwent first methacholine (mch) and then exercise challenge testing (ECT). There was a 1-week interval between the tests. ECT was performed on a bicycle ergometer. Positive result was defined as a 15% decrease in forced expiratory volume in 1 second (FEV(1)) post-exercise. A patient's bronchial reactivity to methacholine was considered as hyperresponsive if PC(20) was less than 8 mg/mL. RESULTS: Mch PC(20) values were significantly lower in patients with both rhinitis and asthma (p < 0.062). Among the 46 patients, mch PC(20) values were significantly different between patients who had positive and negative exercise challenge tests (p = 0.007). All patients with rhinitis alone had a negative ECT and 10 had a positive mch challenge. Change in FEV(1) values after ECT was significantly higher in patients with both rhinitis and asthma compared to those with rhinitis alone (p = 0.009). There was a significant relation between positivity of mch and exercise challenges (p = 0.025). ECT positivity was found to be a significant confounding factor in the diagnosis of asthma (p = 0.001). Specificity and sensitivity values were 100% and 24% for ECT and 68% and 100% for mch, respectively. CONCLUSION: Exercise challenge presents poor diagnostic value for detecting bronchial responsiveness in individuals with allergic rhinitis alone during the pollen season. |
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Authors:
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Betül Ayse Sin; Oznur Akkoca Yildiz; Adile Berna Dursun; Zeynep Misirligil; Yavuz Selim Demirel |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 46 ISSN: 1532-4303 ISO Abbreviation: J Asthma Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: England |
Other Details:
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Languages: eng Pagination: 486-91 Citation Subset: IM |
Affiliation:
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School of Medicine, Division of Allergic Diseases, Ankara University, Dikimevi, 06100-Ankara, Turkey. bsin@medicine.ankara.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / complications, physiopathology* Bronchial Hyperreactivity / diagnosis*, etiology Exercise Test* Female Humans Male Methacholine Chloride / diagnostic use* Respiratory Function Tests Rhinitis, Allergic, Seasonal / complications, diagnosis, physiopathology* Skin Tests |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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