| Airway function and markers of airway inflammation in patients with treated hypothyroidism. | |
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MedLine Citation:
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PMID: 15741445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is increasing evidence of an association between organ specific autoimmune diseases, particularly autoimmune thyroid disease and respiratory morbidity. A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammation and dysfunction. METHODS: Twenty six non-smoking women with treated hypothyroidism and 19 non-smoking controls completed a symptom questionnaire and underwent full lung function tests, capsaicin cough reflex sensitivity measurement, methacholine challenge test, and sputum induction over two visits. RESULTS: Symptoms of cough (p = 0.01), dyspnoea (p = 0.01), sputum production (p = 0.004), and wheeze (p = 0.04) were reported more commonly in patients than controls. Patients with hypothyroidism had heightened cough reflex sensitivity compared with controls (geometric mean concentration of capsaicin causing five coughs: 40 v 108 mmol/l; mean difference 1.4 doubling doses; 95% confidence interval of difference 0.4 to 2.5; p = 0.008) and a significantly higher proportion of patients had airway hyperresponsiveness (methacholine provocative concentration (PC(20)) <8 mg/ml: 38% v 0%; p = 0.016). Patients with hypothyroidism also had a significantly higher induced sputum total neutrophil cell count (p = 0.01), total lymphocyte count (p = 0.02), and sputum supernatant interleukin-8 concentrations (p = 0.048). CONCLUSION: Patients with treated hypothyroidism report more respiratory symptoms and have objective evidence of airway dysfunction and inflammation. |
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Authors:
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S S Birring; R B Patel; D Parker; S McKenna; B Hargadon; W R Monteiro; J F Falconer Smith; I D Pavord |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thorax Volume: 60 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-02 Completed Date: 2005-03-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 249-53 Citation Subset: IM |
Affiliation:
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Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester LE3 9QP, UK. sb134@le.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis Bronchitis / pathology, physiopathology* Case-Control Studies Cross-Sectional Studies Dyspnea / etiology, physiopathology Female Forced Expiratory Volume / physiology Humans Hypothyroidism / pathology, physiopathology*, therapy Leukocyte Count Middle Aged Neutrophils Sputum / cytology Statistics, Nonparametric Vital Capacity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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