Document Detail

Airway function and markers of airway inflammation in patients with treated hypothyroidism.
MedLine Citation:
PMID:  15741445     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is increasing evidence of an association between organ specific autoimmune diseases, particularly autoimmune thyroid disease and respiratory morbidity. A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammation and dysfunction. METHODS: Twenty six non-smoking women with treated hypothyroidism and 19 non-smoking controls completed a symptom questionnaire and underwent full lung function tests, capsaicin cough reflex sensitivity measurement, methacholine challenge test, and sputum induction over two visits. RESULTS: Symptoms of cough (p = 0.01), dyspnoea (p = 0.01), sputum production (p = 0.004), and wheeze (p = 0.04) were reported more commonly in patients than controls. Patients with hypothyroidism had heightened cough reflex sensitivity compared with controls (geometric mean concentration of capsaicin causing five coughs: 40 v 108 mmol/l; mean difference 1.4 doubling doses; 95% confidence interval of difference 0.4 to 2.5; p = 0.008) and a significantly higher proportion of patients had airway hyperresponsiveness (methacholine provocative concentration (PC(20)) <8 mg/ml: 38% v 0%; p = 0.016). Patients with hypothyroidism also had a significantly higher induced sputum total neutrophil cell count (p = 0.01), total lymphocyte count (p = 0.02), and sputum supernatant interleukin-8 concentrations (p = 0.048). CONCLUSION: Patients with treated hypothyroidism report more respiratory symptoms and have objective evidence of airway dysfunction and inflammation.
S S Birring; R B Patel; D Parker; S McKenna; B Hargadon; W R Monteiro; J F Falconer Smith; I D Pavord
Related Documents :
16259795 - Erythrocyte zinc in hospital patients.
91625 - Hypothyroidism as a late sequela in patient with graves' disease treated with antithyro...
6897835 - Sex- and age-related changes of exophthalmos in graves' disease.
17587265 - Growth of patients with congenital hypothyroidism detected by neonatal screening in japan.
9587045 - Prescription of cardiovascular drugs in outpatient care: a survey of outpatients in a g...
9404995 - Ictal and interictal ecd-spect for focus localization in epilepsy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  60     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-02     Completed Date:  2005-03-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester LE3 9QP, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / analysis
Bronchitis / pathology,  physiopathology*
Case-Control Studies
Cross-Sectional Studies
Dyspnea / etiology,  physiopathology
Forced Expiratory Volume / physiology
Hypothyroidism / pathology,  physiopathology*,  therapy
Leukocyte Count
Middle Aged
Sputum / cytology
Statistics, Nonparametric
Vital Capacity / physiology
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome.
Next Document:  Implantation of a pleurovenous shunt for massive chylothorax in a patient with yellow nail syndrome.