Document Detail


Airway function and markers of airway inflammation in patients with treated hypothyroidism.
MedLine Citation:
PMID:  15741445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is increasing evidence of an association between organ specific autoimmune diseases, particularly autoimmune thyroid disease and respiratory morbidity. A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammation and dysfunction. METHODS: Twenty six non-smoking women with treated hypothyroidism and 19 non-smoking controls completed a symptom questionnaire and underwent full lung function tests, capsaicin cough reflex sensitivity measurement, methacholine challenge test, and sputum induction over two visits. RESULTS: Symptoms of cough (p = 0.01), dyspnoea (p = 0.01), sputum production (p = 0.004), and wheeze (p = 0.04) were reported more commonly in patients than controls. Patients with hypothyroidism had heightened cough reflex sensitivity compared with controls (geometric mean concentration of capsaicin causing five coughs: 40 v 108 mmol/l; mean difference 1.4 doubling doses; 95% confidence interval of difference 0.4 to 2.5; p = 0.008) and a significantly higher proportion of patients had airway hyperresponsiveness (methacholine provocative concentration (PC(20)) <8 mg/ml: 38% v 0%; p = 0.016). Patients with hypothyroidism also had a significantly higher induced sputum total neutrophil cell count (p = 0.01), total lymphocyte count (p = 0.02), and sputum supernatant interleukin-8 concentrations (p = 0.048). CONCLUSION: Patients with treated hypothyroidism report more respiratory symptoms and have objective evidence of airway dysfunction and inflammation.
Authors:
S S Birring; R B Patel; D Parker; S McKenna; B Hargadon; W R Monteiro; J F Falconer Smith; I D Pavord
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  60     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-02     Completed Date:  2005-03-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Affiliation:
Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester LE3 9QP, UK. sb134@le.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Bronchitis / pathology,  physiopathology*
Case-Control Studies
Cross-Sectional Studies
Dyspnea / etiology,  physiopathology
Female
Forced Expiratory Volume / physiology
Humans
Hypothyroidism / pathology,  physiopathology*,  therapy
Leukocyte Count
Middle Aged
Neutrophils
Sputum / cytology
Statistics, Nonparametric
Vital Capacity / physiology
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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