| Airway epithelium mediates the anti-inflammatory effects of exercise on asthma. | |
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MedLine Citation:
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PMID: 21236366 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Airway epithelium plays an important role in the asthma physiopathology. Aerobic exercise decreases Th2 response in murine models of allergic asthma, but its effects on the structure and activation of airway epithelium in asthma are unknown. BALB/c mice were divided into control, aerobic exercise, ovalbumin-sensitized and ovalbumin-sensitized plus aerobic exercise groups. Ovalbumin sensitization occurred on days 0, 14, 28, 42, and aerosol challenge from day 21 to day 50. Aerobic exercise started on day 22 and ended on day 50. Total cells and eosinophils were reduced in ovalbumin-sensitized group submitted to aerobic exercise. Aerobic exercise also reduced the oxidative and nitrosative stress and the epithelial expression of Th2 cytokines, chemokines, adhesion molecules, growth factors and NF-kB and P2X7 receptor. Additionally, aerobic exercise increased the epithelial expression of IL-10 in non-sensitized and sensitized animals. These findings contribute to the understanding of the beneficial effects of aerobic exercise for chronic allergic airway inflammation, suggesting an immune-regulatory role of exercise on airway epithelium. |
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Authors:
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Rodolfo Paula Vieira; Alessandra Choqueta de Toledo; Sérgio César Ferreira; Angela Batista Gomes Dos Santos; Maria Cristina Rodrigues Medeiros; Márcia Hage; Thaís Mauad; Milton de Arruda Martins; Marisa Dolhnikoff; Celso Ricardo Fernandes de Carvalho |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-12 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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University of São Paulo, School of Medicine, Department of Physical Therapy (LIM 34), Avenida Doutor Arnaldo 455, São Paulo, Brazil; University Hospital Freiburg, Department of Pneumology, COPD and Asthma Research Group, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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