Document Detail

Airway epithelial cells: current concepts and challenges.
MedLine Citation:
PMID:  18757316     Owner:  NLM     Status:  MEDLINE    
The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epithelium in health and disease.
Ronald G Crystal; Scott H Randell; John F Engelhardt; Judith Voynow; Mary E Sunday
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Proceedings of the American Thoracic Society     Volume:  5     ISSN:  1546-3222     ISO Abbreviation:  Proc Am Thorac Soc     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101203596     Medline TA:  Proc Am Thorac Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  772-7     Citation Subset:  IM    
Weill Cornell Medical College, Cornell University, 1300 York Ave, New York, NY 10065, USA.
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MeSH Terms
Cell Differentiation / physiology
Epithelial Cells / physiology*
Gene Expression
Respiratory Mucosa / cytology*,  physiology
Stem Cells / physiology*

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