| Airway epithelial cells: current concepts and challenges. | |
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MedLine Citation:
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PMID: 18757316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epithelium in health and disease. |
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Authors:
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Ronald G Crystal; Scott H Randell; John F Engelhardt; Judith Voynow; Mary E Sunday |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Proceedings of the American Thoracic Society Volume: 5 ISSN: 1546-3222 ISO Abbreviation: Proc Am Thorac Soc Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-01 Completed Date: 2009-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101203596 Medline TA: Proc Am Thorac Soc Country: United States |
Other Details:
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Languages: eng Pagination: 772-7 Citation Subset: IM |
Affiliation:
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Weill Cornell Medical College, Cornell University, 1300 York Ave, New York, NY 10065, USA. geneticmedicine@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation
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physiology Epithelial Cells / physiology* Gene Expression Humans Respiratory Mucosa / cytology*, physiology Stem Cells / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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