| Airway effects of low concentrations of sulfur dioxide: dose-response characteristics. | |
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MedLine Citation:
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PMID: 6370145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute respiratory effects of exposure to low-level, short-term sulfur dioxide (SO2) were studied in ten asthmatic and ten healthy subjects. Subjects were exposed in an environmental chamber in a double-blind, random sequence to SO2) levels of 0.00, 0.25, 0.50, 0.75, and 1.00 ppm for 40 min. During the first 10 min subjects exercised on a cycloergometer at a level of 450 kpm/min. On separate days, subjects were exposed to 0 and 1.0 ppm SO2 in the absence of exercise. In exercising asthmatic subjects, breathing 1 ppm SO2 resulted in significant changes from baseline in airway resistance (Raw), forced expiratory volume in 1 sec (FEV1.0), maximal expiratory flow at 60% of the vital capacity (VC) below total lung capacity on the partial flow volume curve [MEF40% (P)] as well as reductions in flows at 50% of VC (Vmax50%). None of these parameters showed significant changes for exposures to 0.5 ppm or less, with the exception of small decreases (i.e., less than 0.2 L/sec) in Vmax50% at 0.25 and 0.5 ppm. Ten minutes after the end of exercise, there were no statistically significant differences from baseline, even though SO2 was still present in the chamber atmosphere. For asthmatic subjects, the average changes in Raw, FEV1.0, MEF40%(P), and Vmax50% increased as SO2 levels increased, suggestive of a dose-response relationship with a consistent effect first seen at 0.75 ppm. In individual exercising asthmatics, responses may occur at levels of SO2 below 0.75 ppm. No changes were seen in healthy individuals on any day, or in asthmatic subjects at rest.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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E N Schachter; T J Witek; G J Beck; H B Hosein; G Colice; B P Leaderer; W Cain |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of environmental health Volume: 39 ISSN: 0003-9896 ISO Abbreviation: Arch. Environ. Health Publication Date: 1984 Jan-Feb |
Date Detail:
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Created Date: 1984-05-23 Completed Date: 1984-05-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0212627 Medline TA: Arch Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 34-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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drug effects* Asthma / physiopathology* Bronchi / drug effects Clinical Trials as Topic Dose-Response Relationship, Drug Double-Blind Method Environment, Controlled Humans Physical Exertion Respiratory Function Tests Sulfur Dioxide / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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7446-09-5/Sulfur Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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