| Airway distensibility and volume recruitment with lung inflation in COPD. | |
| | |
MedLine Citation:
|
PMID: 20651219 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The effects of full lung inflation on respiratory conductance (Grs) and reactance (Xrs) were measured in 15 subjects with moderate to severe chronic obstructive pulmonary disease (COPD) and 11 matched healthy control subjects. Airway distensibility was estimated from the ratio of the difference of Grs between functional residual capacity and total lung capacity to the relevant changes in lung volume (ΔGrs/ΔVl) or transpulmonary pressure (ΔGrs/ΔPtp). Similar analysis was applied to Xrs to estimate lung volume recruitment (ΔXrs/ΔVl or ΔXrs/ΔPtp). The extent of emphysema in COPD subjects was estimated from the percentage of low attenuation area (LAA) at high-resolution computed tomography. At baseline, ΔGrs/ΔVl and ΔXrs/ΔVl were significantly less in COPD than control subjects, indicating less distensibility and volume recruitment in the former. In COPD, ΔGrs/ΔPtp and ΔXrs/ΔPtp were uncorrelated with LAA but correlated with 1-s forced expiratory volume and with each other. After albuterol, both ΔGrs/ΔPtp and ΔGrs/ΔVl became significantly and negatively correlated with LAA, while ΔXrs/ΔPtp and ΔXrs/ΔVl decreased significantly independently of LAA. Moreover, ΔGrs/ΔPtp and ΔXrs/ΔPtp with lung inflation were no longer correlated with each other, suggesting that airway distensibility and volume recruitment were affected differently by airway smooth muscle tone. Assuming that Grs mainly reflects airway caliber and Xrs the number of ventilated lung units, we conclude that airway smooth muscle contributes to airway stiffness and ventilation inhomogeneities in COPD subjects with prevailing bronchitis but only to the latter in those with more emphysema. We suggest that changes of airway distensibility and volume recruitment with a bronchodilator may be useful for disease phenotyping. |
| | |
Authors:
|
Simonetta Baldi; Raffaele Dellacà; Leonardo Govoni; Roberto Torchio; Andrea Aliverti; Pasquale Pompilio; Luciano Corda; Claudio Tantucci; Carlo Gulotta; Vito Brusasco; Riccardo Pellegrino |
Related Documents
:
|
1399979 - Static lung-lung interactions in unilateral emphysema. 7378229 - Dynamic behaviour of the chest and of the abdomen in anaesthetized piglets during rapid... 6140939 - Pulmonary effects in man of oral prizidilol hydrochloride (sk&f 92657), a new antihyper... 22410469 - Influence of a prolonged lateral position on induction of spinal anesthesia for cesarea... 9017849 - Respiratory mechanics in rabbits ventilated with different tidal volumes. 8575579 - Pressure-volume analysis of the lung with an exponential and linear-exponential model i... 12180249 - Monitoring devices for falls and syncope. 8746939 - Principles of interpretation of coronary velocity and pressure tracings. 7485569 - Pressure wave propagation in a multibranched model of the human upper limb. |
Publication Detail:
|
Type: Journal Article Date: 2010-07-22 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 109 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1019-26 Citation Subset: IM |
Affiliation:
|
Fisiopatologia Respiratoria, Centro Medico di Riabilitazione di Montescano, Fondazione Salvatore Maugeri IRCCS, Via per Montescano, 31, 27040 Montescano (Pavia), Italy. simonetta.baldi@fsm.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.
Next Document: Influence of dietary fatty acid composition and exercise on changes in fat oxidation from a high-fat...