Document Detail

Airway distensibility in healthy and asthmatic subjects: effect of lung volume history.
MedLine Citation:
PMID:  10749837     Owner:  NLM     Status:  MEDLINE    
Anatomic dead space (VD) is known to increase with end-inspiratory lung volume (EILV), and the gradient of the relationship has been proposed as an index of airway distensibility (DeltaVD). The aims of this study were to apply a rapid method for measuring DeltaVD and to determine whether it was affected by lung volume history. VD of 16 healthy and 16 mildly asthmatic subjects was measured at a number of known EILVs by using a tidal breathing, CO(2)-washout method. The effect of lung volume history was assessed by using three tidal breathing regimens: 1) three discrete EILVs (low/medium/high; LMH); 2) progressively decreasing EILVs from total lung capacity (TLC; TLC-RV); and 3) progressively increasing EILVs from residual volume (RV; RV-TLC). DeltaVD was lower in the asthmatic group for the LMH (25.3 +/- 2.24 vs. 21.2 +/- 1.66 ml/l, means +/- SE) and TLC-RV (24. 3 +/- 1.69 vs. 18.7 +/- 1.16 ml/l) regimens. There was a trend for a lower DeltaVD in the asthmatic group for the RV-TLC regimen (23.3 +/- 2.19 vs. 18.8 +/- 1.68 ml/l). There was no difference in DeltaVD between groups. In conclusion, mild asthmatic subjects have stiffer airways than normal subjects, and this is not obviously affected by lung volume history.
D P Johns; J Wilson; R Harding; E H Walters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-17     Completed Date:  2000-05-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1413-20     Citation Subset:  IM    
Department of Respiratory Medicine, The Alfred Hospital and Monash University Medical School, Prahran, Melbourne, Victoria 3181, Australia.
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MeSH Terms
Asthma / physiopathology*
Bronchial Hyperreactivity / physiopathology
Bronchial Provocation Tests
Bronchoconstrictor Agents / diagnostic use,  pharmacology
Carbon Dioxide / analysis
Lung Compliance / drug effects,  physiology*
Lung Volume Measurements*
Methacholine Chloride / diagnostic use,  pharmacology
Reference Values
Regression Analysis
Reproducibility of Results
Respiratory Mechanics
Reg. No./Substance:
0/Bronchoconstrictor Agents; 124-38-9/Carbon Dioxide; 62-51-1/Methacholine Chloride

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