| Airway bypass improves the mechanical properties of explanted emphysematous lungs. | |
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MedLine Citation:
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PMID: 18669815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: By creating artificial communications through bronchial walls into the parenchyma of explanted lungs (airway bypass), we expect to decrease the amount of gas trapped and to increase the rate and volume of air expelled during forced expirations. OBJECTIVES: To describe the mechanism by which airway bypass improves the mechanical properties of the emphysematous lung. METHODS: Lung compartments and mechanics were measured before and after airway bypass, which was created by placement of three or four stent-supported fenestrations in 10 emphysematous lungs removed at transplantation surgery. MEASUREMENTS AND MAIN RESULTS: Minimal volume after passive deflation decreased by a mean of 1.54 L (range, 0.7-2.5 L) or 60% (range, 37-86%). Explanted VC increased by 1.30 L or 132% (range, 78-318%). Maximal expiratory flows and volumes increased. Flow resistance decreased. CONCLUSIONS: Because these data show that airway bypass improves the mechanics of breathing in severely emphysematous lungs in vitro, there is now strong empirical support that this procedure can improve ventilatory function in patients by reducing gas trapping and flow resistance. |
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Authors:
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Cliff K Choong; Peter T Macklem; John A Pierce; Nitin Das; Barbara A Lutey; Carlo O Martinez; Joel D Cooper |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural Date: 2008-07-31 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 178 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-23 Completed Date: 2008-12-01 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 902-5 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessel Prosthesis Bronchi / physiopathology*, surgery* Forced Expiratory Volume Humans Lung / pathology, physiopathology*, surgery* Lung Transplantation Lung Volume Measurements Pulmonary Emphysema / physiopathology*, surgery* Pulmonary Ventilation Stents |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL62194/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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