Document Detail

Airway stenting and tracheobronchoplasty improve respiratory symptoms in Mounier-Kuhn syndrome.
MedLine Citation:
PMID:  21493699     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mounier-Kuhn syndrome (MKS) is a condition characterized by tracheobronchomegaly resulting from the loss or atrophy of musculoelastic fibers within the airway wall. Concomitant tracheobronchomalacia is seen in most patients with MKS, often leading to significant respiratory compromise due to bronchiectasis, increased dead space, and impaired secretion clearance.
METHODS: We report a series of 12 patients with MKS and tracheobronchomalacia who were evaluated at our institution for significant respiratory problems. Stent trials were conducted in 10 patients, with seven proceeding to operative tracheobronchoplasty (TBP) and one continuing with long-term stent placement. One patient underwent TBP without prior stent placement. Of the remaining three patients, two had no improvement with trials of stent placement, and a stent could not be placed in the third because of a large tracheal diameter.
RESULTS: Compared with baseline values, clinically significant improvements in health-related quality-of-life measures and pulmonary function testing were seen in patients who underwent central airway stabilization (n = 9). Complications of both stent placement and TBP were generally mild. However, one death was reported in the surgical group secondary to an exacerbation of preexisting interstitial pneumonia.
CONCLUSIONS: An aggressive approach that targets central airway stabilization may improve outcomes for patients with MKS.
David D Odell; Archan Shah; Sidhu P Gangadharan; Adnan Majid; Gaetane Michaud; Felix Herth; Armin Ernst
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2011-04-14
Journal Detail:
Title:  Chest     Volume:  140     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-05     Completed Date:  2011-12-07     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-73     Citation Subset:  AIM; IM    
Division of Thoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Aged, 80 and over
Bronchi / physiopathology*
Bronchoscopy / instrumentation,  methods*
Middle Aged
Outcome Assessment (Health Care)
Prospective Studies
Quality of Life
Respiratory Function Tests
Retrospective Studies
Tomography, X-Ray Computed
Trachea / physiopathology*
Tracheobronchomalacia / physiopathology,  radiography,  therapy*
Tracheobronchomegaly / physiopathology,  radiography,  therapy*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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