Document Detail

Airway Inflammation and Hypothalamic-Pituitary-Adrenal Axis Activity in Asthmatic Adults With Depression.
MedLine Citation:
PMID:  23323569     Owner:  NLM     Status:  Publisher    
Objective: To investigate the features of airway inflammation and hypothalamic-pituitary-adrenal axis (HPAA) activity in patients with asthma accompanied by depression. Methods: Adult asthmatics were recruited and enrolled into one of two groups based on scores on the Hamilton Depression Rating Scale (HAMD): asthmatics with depression (HAMD score ≥8, n=23), and asthmatics without depression (HAMD score <8, n=41). In addition, 27 healthy individuals and 21 adults with depression only were enrolled as controls. Induced sputum and blood samples were collected for measurement of cytokines and other inflammatory factors. The diurnal rhythm profiles of salivary cortisol and other hormones were obtained for assessment of the HPAA activity. Results: For the group of asthmatics with depression, the mean HAMD score was 19.0, and for the group of asthmatics without depression, the HAMD score averaged 4.9(P<0.001). Serum and sputum tumor necrosis factor alpha (TNF-α) were significantly higher in asthmatics with depression than those in the other groups (P<0.05) while serum interferon gamma (IFN-γ) was lower in asthmatics with depression than that in the other groups (P<0.05). 24 h urinary cortisol, salivary cortisol at 8 a.m. and 4 p.m. were lower in asthmatics with depression compared to other groups (P<0.05). Conclusions: As compared to healthy individuals and those with asthma or depression alone, individuals with comorbid depression and asthma showed the highest level of pro-inflammatory cytokines and the lowest level of anti-inflammatory cytokines and cortisol. These observations may serve as a valuable reference for diagnosis and clinic therapies of depression in asthmatics.
Yi-Jie Du; Bei Li; Yu-Xue Cao; Jing-Cheng Dong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  -     ISSN:  1532-4303     ISO Abbreviation:  J Asthma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Lab of Integrative Medicine for Lung, Inflammation and Cancers, Huashan Hospital, Fudan University , Shanghai , China.
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