| Airway Clearance of Apoptotic Cells in COPD. | |
| | |
MedLine Citation:
|
PMID: 20450476 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Apoptosis of bronchial epithelial cells and the phagocytic clearance of these cells by alveolar macrophages (a process termed efferocytosis) are integral processes leading to repair of airway epithelial injury. Efferocytosis allows for the removal of apoptotic material with minimal inflammation and prevents the development of secondary necrosis and ongoing inflammation. Defective efferocytosis and the increased presence of apoptotic cells have been identified in the airways of subjects with chronic obstructive pulmonary disease (COPD). There are three major potential causes for this accumulation of apoptotic cells: (i) increased apoptosis per se as a result of an increase in apoptotic mediators, (ii) defects in the recognition of apoptotic cells by AM and (iii) failure to clear the unwanted cells by the process of efferocytosis. The implications of these processes in COPD and novel treatment strategies aimed at improving clearance of apoptotic cells form the focus of the present review. |
| | |
Authors:
|
Violet R S Mukaro; Sandra Hodge |
Related Documents
:
|
19783676 - Enhanced th2 cell differentiation and allergen-induced airway inflammation in zfp35-def... 19440656 - Intranasal challenge with increasing ovalbumin doses differently affects airway hyperre... 18983986 - Crosstalk between the ahr signaling pathway and circadian rhythm. 17615396 - Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. 21322996 - T rosette assay: in vitro correlate of cellular immunity. 20442856 - Natural regulatory t cells in malaria: host or parasite allies? |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current drug targets Volume: 12 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 460-8 Citation Subset: IM |
Affiliation:
|
Department of Thoracic Medicine, Royal Adelaide Hospital and Lung Research Laboratory, Hanson Institute, Adelaide, South Australia. violet.mukaro@adelaide.edu.au. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tyrosine kinase receptor transactivation associated to G protein-coupled receptors.
Next Document: Predictions of the ADMET Properties of Candidate Drug Molecules Utilizing Different QSAR/QSPR Modell...