Document Detail

Airflow limitation in morbidly obese, nonsmoking men.
MedLine Citation:
PMID:  2378649     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To determine the effect of obesity on pulmonary function.
DESIGN: Case-control study, using nonobese, age- and height-matched [corrected] nonsmokers.
SETTING: Metabolic and obesity clinics of two major teaching hospitals.
PATIENTS: One hundred and three obese, lifelong nonsmokers without cardiopulmonary disease.
CONTROLS: One hundred and ninety healthy, nonobese nonsmokers recruited from among hospital personnel.
MEASUREMENTS AND MAIN RESULTS: Complete pulmonary function measurements in all patients and controls. These measurements included maximum expiratory flow-volume curve, lung volumes and airway resistance using body plethysmograph, single-breath diffusing capacity for carbon monoxide, and total lung capacity using the helium dilution technique. Obese persons were found to have lower functional residual capacity, expiratory reserve volume, and total lung capacity by helium dilution than nonobese controls. In addition, residual volume and diffusing capacity were higher in the obese group. Finally, we found that obese men, but not women, had reduced maximum expiratory flow rates at 50% and 75% of exhaled vital capacity.
CONCLUSION: Obesity may contribute independently of smoking habits to chronic airflow limitation in men.
I Rubinstein; N Zamel; L DuBarry; V Hoffstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  112     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-28     Completed Date:  1990-06-28     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  828-32     Citation Subset:  AIM; IM    
St. Michael's Hospital, Toronto, Ontario.
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MeSH Terms
Case-Control Studies
Lung Diseases, Obstructive / etiology
Maximal Expiratory Flow-Volume Curves
Middle Aged
Obesity, Morbid / complications,  physiopathology*
Pulmonary Ventilation / physiology*
Respiratory Function Tests
Sex Factors
Statistics as Topic
Comment In:
Ann Intern Med. 1990 Dec 15;113(12):993-4   [PMID:  2240925 ]
Erratum In:
Ann Intern Med 1990 Aug 15;113(4):334

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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