Document Detail

Airflow Limitation in Chronic Obstructive Pulmonary Disease: Ratio and Difference of Percentage of Low-attenuation Lung Regions in Paired Inspiratory/Expiratory Computed Tomography.
MedLine Citation:
PMID:  25086954     Owner:  NLM     Status:  Publisher    
RATIONALE AND OBJECTIVES: The purpose of this study was to analyze the relationship between airflow limitation and two types of computed tomography (CT) measurements: expiratory/inspiratory (E/I) ratio and E/I difference of percentage of low-attenuation lung regions (LAA%).
MATERIALS AND METHODS: Thirty patients who underwent inspiratory and expiratory CT scans were included in this study. The CT data were used to calculate the LAA% E/I ratio and E/I difference. Other types of CT measurements were also obtained, including the E/I ratio and E/I difference of lung volume, mean lung density, standard deviation, skewness, and kurtosis. LAA% was calculated at 20 thresholds (-990 to -800 HU). Pearson's correlation between the measurements and forced expiratory flow in 1 second was used to determine the efficacy of LAA% E/I ratio and E/I difference. P values of <5.88 × 10(-5) were considered statistically significant with Bonferroni correction.
RESULTS: The LAA% E/I ratio and E/I difference significantly correlated with forced expiratory flow in 1 second. The best correlation coefficient for the LAA% E/I ratio was -0.699 (P = 1.75 × 10(-5)) and for the LAA% E/I difference was -0.723 (P = 6.53 × 10(-6)). The best correlation coefficient for the LAA% E/I difference was stronger than that for the other types of CT measurements.
CONCLUSIONS: The LAA% E/I ratio and E/I difference significantly correlated with airflow limitation in chronic obstructive pulmonary disease.
Mizuho Nishio; Sumiaki Matsumoto; Hisanobu Koyama; Yoshiharu Ohno; Kazuro Sugimura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-30
Journal Detail:
Title:  Academic radiology     Volume:  -     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.
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