Document Detail

Airborne antibiotic concentrations in a swine feeding operation.
MedLine Citation:
PMID:  18075012     Owner:  NLM     Status:  MEDLINE    
During the past 50 years, it has become common practice in the U.S. to add antibiotics to livestock feed to reduce disease and promote growth. Use of antibiotics in this manner has become the source of increasing controversy because overuse of antibiotics is suspected of leading to resistance in bacteria that cause human diseases. The purpose of this study was to measure airborne antibiotic concentrations in a swine production facility that routinely included antibiotics in feed. Samples were collected in a hog facility that included rooms devoted to farrowing, nursery, and growing operations. Analytical methods were developed to measure concentrations of the antibiotics tylosin and lincomycin in air samples. Tylosin was mixed in the feed in some of the rooms in the facility. While lincomycin was not added during this study, it had been used in this facility in the past and therefore was included in the analytical testing. Inhalable (n = 34), respirable (n = 37), and high-volume (n = 16) dust samples were collected on PVC filters over a two-month period. Tylosin concentrations were above the limit of quantification (LOQ) in 93% of the samples, while lincomycin concentrations were above the LOQ in only 9% of the samples (LOQ = 0.04 ng/sample). The average tylosin concentrations were 3, 18, and 49 ng/m3 in the respirable, inhalable, and high-volume samples, respectively. No occupational or environmental worker exposure criteria currently exist for antibiotics in air. The results of this study may be used to estimate potential swine production worker exposures and to further study the association between these exposures and health effects.
M W Murphy; W T Sanderson; J D Vargo
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of agricultural safety and health     Volume:  13     ISSN:  1074-7583     ISO Abbreviation:  J Agric Saf Health     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-13     Completed Date:  2008-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9613956     Medline TA:  J Agric Saf Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-66     Citation Subset:  IM    
University of Iowa, Iowa City 52242, USA.
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MeSH Terms
Air Pollutants, Occupational / chemistry*
Air Pollution, Indoor*
Animal Feed / analysis
Animal Husbandry*
Anti-Bacterial Agents / chemistry*
Lincomycin / chemistry
Occupational Exposure*
Tylosin / chemistry
Grant Support
T42/CCT22958-01/CC/CDC HHS
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Anti-Bacterial Agents; 1401-69-0/Tylosin; 154-21-2/Lincomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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