Document Detail

Airborne allergic contact dermatitis from tylosin in pharmacy compounders and cross-sensitization to macrolide antibiotics.
MedLine Citation:
PMID:  23010831     Owner:  NLM     Status:  MEDLINE    
Tylosin is a broad-spectrum macrolide antibiotic that is restricted to veterinary use. Allergic contact dermatitis (ACD) caused by tylosin has been reported in the literature from the farming industry and veterinary medicine. It is also reported as the most common antibiotic to cause ACD in the previously mentioned occupational settings. We present 2 cases of airborne ACD from tylosin among veterinary pharmaceutical compounding technicians. To our knowledge, only one other case of patch test-confirmed tylosin ACD has been reported in the manufacturing setting. Based on our results, cross-sensitization to other clinically relevant macrolides does not appear to be a concern. Our cases highlight the importance of patch testing among pharmaceutical compounders where the incidence of an airborne contact may be greater, given that the exposure is to the powdered form of potential allergens.
Viba Malaiyandi; Marie Claude Houle; Sandy Skotnicki-Grant
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatitis : contact, atopic, occupational, drug     Volume:  23     ISSN:  1710-3568     ISO Abbreviation:  Dermatitis     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-26     Completed Date:  2013-05-09     Revised Date:  2013-08-30    
Medline Journal Info:
Nlm Unique ID:  101207335     Medline TA:  Dermatitis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  227-30     Citation Subset:  IM    
Department of Occupational and Environmental Health, St Michael's Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Air Pollutants, Occupational / adverse effects*
Anti-Bacterial Agents / adverse effects*,  immunology
Cross Reactions
Dermatitis, Allergic Contact / etiology*
Drug Compounding
Facial Dermatoses / chemically induced
Macrolides / adverse effects,  immunology
Middle Aged
Occupational Exposure / adverse effects*
Patch Tests
Tylosin / adverse effects*,  immunology
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Anti-Bacterial Agents; 0/Macrolides; 1401-69-0/Tylosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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