Document Detail

Air saturation of the medium reduces the rate of phosphorylating oxidation of succinate in isolated mitochondria.
MedLine Citation:
PMID:  1468556     Owner:  NLM     Status:  MEDLINE    
Rat brain mitochondria were isolated and their respiration was polarographically measured without contact with air oxygen. Gas-saturated experimental mixtures close to the in vivo partial oxygen pressure (normoxic) were compared with the air-saturated, i.e. hyperoxic, mixtures. The rate of phosphorylating oxidation of added succinate under normoxic conditions was found to be 70-100% higher compared with hyperoxic ones. The addition of succinate dehydrogenase activators results in a more than two-fold stronger stimulation of succinate oxidation under normoxia than under hyperoxia. Thiol group donors are shown to stimulate respiration under hyperoxia and not under normoxia. Hyperoxic conditions prevented oxidation of the low succinate concentrations corresponding to the physiological ones.
V A Khazanov; A N Poborsky; M N Kondrashova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  314     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-25     Completed Date:  1993-01-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  264-6     Citation Subset:  IM    
Institute of Pharmacology, Russian Academy of Medical Science, Tomsk.
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MeSH Terms
Mitochondria / metabolism*
Oxygen / metabolism*
Succinate Dehydrogenase / metabolism
Succinates / metabolism*
Succinic Acid
Reg. No./Substance:
0/Succinates; 110-15-6/Succinic Acid; 7782-44-7/Oxygen; EC Dehydrogenase

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