| Air saturation of the medium reduces the rate of phosphorylating oxidation of succinate in isolated mitochondria. | |
| | |
MedLine Citation:
|
PMID: 1468556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rat brain mitochondria were isolated and their respiration was polarographically measured without contact with air oxygen. Gas-saturated experimental mixtures close to the in vivo partial oxygen pressure (normoxic) were compared with the air-saturated, i.e. hyperoxic, mixtures. The rate of phosphorylating oxidation of added succinate under normoxic conditions was found to be 70-100% higher compared with hyperoxic ones. The addition of succinate dehydrogenase activators results in a more than two-fold stronger stimulation of succinate oxidation under normoxia than under hyperoxia. Thiol group donors are shown to stimulate respiration under hyperoxia and not under normoxia. Hyperoxic conditions prevented oxidation of the low succinate concentrations corresponding to the physiological ones. |
| | |
Authors:
|
V A Khazanov; A N Poborsky; M N Kondrashova |
Related Documents
:
|
21876896 - Development of educational hypermedia to teach an arterial blood pressure measurement p... 16205326 - Evidence for myocardial defects under extreme acute normovolemic hemodilution with hydr... 637806 - Blood gas tension and development of lung damage in mice exposed to oxygen at 1 ata. 1655346 - Zinc improves the filterability of sickle erythrocytes at intermediate oxygen partial p... 3356456 - An impedance method for blood pressure measurement in awake rats without preheating. 11903326 - Impact of physical and physiological factors on arterial function. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: FEBS letters Volume: 314 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1992 Dec |
Date Detail:
|
Created Date: 1993-01-25 Completed Date: 1993-01-25 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 264-6 Citation Subset: IM |
Affiliation:
|
Institute of Pharmacology, Russian Academy of Medical Science, Tomsk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Air Animals Kinetics Male Mitochondria / metabolism* Oxidation-Reduction Oxygen / metabolism* Phosphorylation Rats Succinate Dehydrogenase / metabolism Succinates / metabolism* Succinic Acid |
| Chemical | |
Reg. No./Substance:
|
0/Succinates; 110-15-6/Succinic Acid; 7782-44-7/Oxygen; EC 1.3.99.1/Succinate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: DNA-specific antiidiotypic antibodies in the sera of patients with autoimmune diseases.
Next Document: Investigation of the neighbour relationships between photosystem II polypeptides in the two types of...