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Air pressure-induced susceptibility changes in vascular reactivity studies using BOLD MRI.
MedLine Citation:
PMID:  23172781     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To investigate whether compressed air during air-cuff inflation in vascular reactivity studies could induce aberrant blood oxygenation level-dependent (BOLD) signal change. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) experiments were performed on a whole-body 3 T scanner. The pattern of T2* signal change measured from a phantom simulating the lower limb was assessed while a thigh cuff was inflated and deflated. MR spectroscopy was performed on a head phantom wrapped using a hand-cuff to determine the relationship between water peak linewidth and applied cuff pressure. Calf muscles from 14 normal subjects were examined to identify aberrant T2* signal changes in the occluded and nonoccluded legs. RESULTS: A sudden T2* signal drop was observed in the phantom on initiation of cuff inflation with subsequent signal change being dependent on cuff pressure. Water peak linewidth increased linearly with cuff pressure (r(2) = 0.94). Aberrant T2* signal changes were observed in both the occluded and nonoccluded legs. CONCLUSION: Compressed air due to cuff inflation directly affects local magnetic field susceptibility. The T2* sequence is sensitive to local field disturbances induced by an inflated cuff. Muscle BOLD results are affected by high-pressure air, with a sudden drop in T2* signal being a characteristic feature of this induced effect. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc.
Authors:
David K W Yeung; James F Griffith; Alvin F W Li; Heather T Ma; Jing Yuan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  -     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Imaging and Interventional Radiology, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. dkyeung@cuhk.edu.hk.
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