| Air pressure-induced susceptibility changes in vascular reactivity studies using BOLD MRI. | |
MedLine Citation:
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PMID: 23172781 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To investigate whether compressed air during air-cuff inflation in vascular reactivity studies could induce aberrant blood oxygenation level-dependent (BOLD) signal change. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) experiments were performed on a whole-body 3 T scanner. The pattern of T2* signal change measured from a phantom simulating the lower limb was assessed while a thigh cuff was inflated and deflated. MR spectroscopy was performed on a head phantom wrapped using a hand-cuff to determine the relationship between water peak linewidth and applied cuff pressure. Calf muscles from 14 normal subjects were examined to identify aberrant T2* signal changes in the occluded and nonoccluded legs. RESULTS: A sudden T2* signal drop was observed in the phantom on initiation of cuff inflation with subsequent signal change being dependent on cuff pressure. Water peak linewidth increased linearly with cuff pressure (r(2) = 0.94). Aberrant T2* signal changes were observed in both the occluded and nonoccluded legs. CONCLUSION: Compressed air due to cuff inflation directly affects local magnetic field susceptibility. The T2* sequence is sensitive to local field disturbances induced by an inflated cuff. Muscle BOLD results are affected by high-pressure air, with a sudden drop in T2* signal being a characteristic feature of this induced effect. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc. |
Authors:
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David K W Yeung; James F Griffith; Alvin F W Li; Heather T Ma; Jing Yuan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-21 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Imaging and Interventional Radiology, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. dkyeung@cuhk.edu.hk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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