Document Detail


Air pollution, inflammation and preterm birth in Mexico City: study design and methods.
MedLine Citation:
PMID:  23177781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm birth is one of the leading causes of perinatal mortality and is associated with long-term adverse health consequences for surviving infants. Preterm birth rates are rising worldwide, and no effective means for prevention currently exists. Air pollution exposure may be a significant cause of prematurity, but many published studies lack the individual, clinical data needed to elucidate possible biological mechanisms mediating these epidemiological associations. This paper presents the design of a prospective study now underway to evaluate those mechanisms in a cohort of pregnant women residing in Mexico City. We address how air quality may act together with other factors to induce systemic inflammation and influence the duration of pregnancy. Data collection includes: biomarkers relevant to inflammation in cervico-vaginal exudate and peripheral blood, along with full clinical information, pro-inflammatory cytokine gene polymorphisms and air pollution data to evaluate spatial and temporal variability in air pollution exposure. Samples are collected on a monthly basis and participants are followed for the duration of pregnancy. The data will be used to evaluate whether ambient air pollution is associated with preterm birth, controlling for other risk factors. We will evaluate which time windows during pregnancy are most influential in the air pollution and preterm birth association. In addition, the epidemiological study will be complemented with a parallel toxicology invitro study, in which monocytic cells will be exposed to air particle samples to evaluate the expression of biomarkers of inflammation.
Authors:
Marie S O'Neill; Alvaro Osornio-Vargas; Miatta A Buxton; Brisa N Sánchez; Leonora Rojas-Bracho; Marisol Castillo-Castrejon; Irina B Mordhukovich; Daniel G Brown; Felipe Vadillo-Ortega
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-21
Journal Detail:
Title:  The Science of the total environment     Volume:  448     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollution*
Biological Markers / metabolism
Cytokines / genetics,  metabolism
Environmental Monitoring*
Female
Humans
Inflammation / epidemiology*
Mexico / epidemiology
Polymorphism, Genetic
Pregnancy
Premature Birth / epidemiology*
Prospective Studies
Risk Factors
Time Factors
Grant Support
ID/Acronym/Agency:
P30 ES017885/ES/NIEHS NIH HHS; R01 ES016932/ES/NIEHS NIH HHS; R01 ES016932/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines
Comments/Corrections

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