Document Detail

Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors.
MedLine Citation:
PMID:  17637925     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Numerous studies have found that ambient air pollution has been associated with cardiovascular disease exacerbation. OBJECTIVES: Given previous findings, we hypothesized that particulate air pollution might induce systemic inflammation in myocardial infarction (MI) survivors, contributing to an increased vulnerability to elevated concentrations of ambient particles. METHODS: A prospective longitudinal study of 1,003 MI survivors was performed in six European cities between May 2003 and July 2004. We compared repeated measurements of interleukin 6 (IL-6), fibrinogen, and C-reactive protein (CRP) with concurrent levels of air pollution. We collected hourly data on particle number concentrations (PNC), mass concentrations of particulate matter (PM) < 10 microm (PM(10)) and < 2.5 microm (PM(2.5)), gaseous pollutants, and meteorologic data at central monitoring sites in each city. City-specific confounder models were built for each blood marker separately, adjusting for meteorology and time-varying and time-invariant covariates. Data were analyzed with mixed-effects models. RESULTS: Pooled results show an increase in IL-6 when concentrations of PNC were elevated 12-17 hr before blood withdrawal [percent change of geometric mean, 2.7; 95% confidence interval (CI), 1.0-4.6]. Five day cumulative exposure to PM(10) was associated with increased fibrinogen concentrations (percent change of arithmetic mean, 0.6; 95% CI, 0.1-1.1). Results remained stable for smokers, diabetics, and patients with heart failure. No consistent associations were found for CRP. CONCLUSIONS: Results indicate an immediate response to PNC on the IL-6 level, possibly leading to the production of acute-phase proteins, as seen in increased fibrinogen levels. This might provide a link between air pollution and adverse cardiac events.
Regina Rückerl; Sonja Greven; Petter Ljungman; Pasi Aalto; Charalambos Antoniades; Tom Bellander; Niklas Berglind; Christina Chrysohoou; Francesco Forastiere; Bénédicte Jacquemin; Stephanie von Klot; Wolfgang Koenig; Helmut Küchenhoff; Timo Lanki; Juha Pekkanen; Carlo A Perucci; Alexandra Schneider; Jordi Sunyer; Annette Peters;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental health perspectives     Volume:  115     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1072-80     Citation Subset:  IM    
GSF National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany.
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MeSH Terms
Air Pollution*
C-Reactive Protein / metabolism*
Fibrinogen / metabolism*
Inflammation / chemically induced*
Interleukin-6 / blood*
Myocardial Infarction / blood*
Reg. No./Substance:
0/Interleukin-6; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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