Document Detail

Air pollution: from lung to heart.
MedLine Citation:
PMID:  16511705     Owner:  NLM     Status:  MEDLINE    
Epidemiological, clinical, and experimental evidence correlates current levels of ambient air pollution with both respiratory and cardiovascular effects. Oxidative stress, inflammation, induction of a pro-coagulatory state and dysfunction of the autonomic nervous system appear to play a major role. Acute effects include changes in lung function, heart rate, blood pressure and inflammatory state, and clinical measures such as respiratory symptoms, thrombosis, myocardial infarction, arrhythmia, stroke, and death. In addition, there is an increase in the use of health care resources due to these effects. Long-term consequences of cumulated exposure include adverse effects on lung growth, chronic bronchitis, lung cancer, and probably the development of asthma and atherosclerosis. These morbidities ultimately lead to shorter life expectancy. Host factors including genotype are important modifiers of the effects of air pollution. Further research will help identify susceptible subgroups and disentangle specific effects and mechanisms associated with various constituents and sources of air pollution.
Nino Künzli; Ira B Tager
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Swiss medical weekly     Volume:  135     ISSN:  1424-7860     ISO Abbreviation:  Swiss Med Wkly     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-03-02     Completed Date:  2006-03-24     Revised Date:  2011-02-15    
Medline Journal Info:
Nlm Unique ID:  100970884     Medline TA:  Swiss Med Wkly     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  697-702     Citation Subset:  IM    
Dept. of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar, Los Angeles, CA 90033, USA.
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MeSH Terms
Air Pollution / adverse effects*
Cardiovascular Diseases / etiology*,  physiopathology,  prevention & control
Environmental Exposure / adverse effects*,  prevention & control
Models, Biological
Respiratory Tract Diseases / etiology*,  physiopathology,  prevention & control
Risk Factors
Grant Support

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