Document Detail


Air pollution and asthma severity in adults.
MedLine Citation:
PMID:  19017701     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/OBJECTIVES: There is evidence that exposure to air pollution affects asthma, but the effect of air pollution on asthma severity has not been addressed. The aim was to assess the relation between asthma severity during the past 12 months and home outdoor concentrations of air pollution.
METHODS: Asthma severity over the past 12 months was assessed in two complementary ways among 328 adult asthmatics from the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) examined between 1991 and 1995. The four-class severity score integrated clinical events and type of treatment. The five-level asthma score is based only on the occurrence of symptoms. Nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)) and ozone (O(3)) concentrations were assigned to each residence using two different methods. The first was based on the closest monitor data from 1991 to 1995. The second consisted of spatial models that used geostatistical interpolations and then assigned air pollutants to the geo-coded residences (1998).
RESULTS: Higher asthma severity score was significantly related to the 8-hour average of ozone during April-September (O(3)-8 h) and the number of days (O(3)-days) with 8-hour ozone averages above 110 microg.m(-3) (for a 36-day increase, equivalent to the interquartile range, in O(3)-days, odds ratio 2.22 (95% confidence interval 1.61 to 3.07) for one class difference in score). Adjustment for age, sex, smoking habits, occupational exposure, and educational level did not alter results. Asthma severity was unrelated to NO(2). Both exposure assessment methods and severity scores resulted in very similar findings. SO(2) correlated with severity but reached statistical significance only for the model-based assignment of exposure.
CONCLUSIONS: The observed associations between asthma severity and air pollution, in particular O(3), support the hypothesis that air pollution at levels far below current standards increases asthma severity.
Authors:
E Rage; V Siroux; N Künzli; I Pin; F Kauffmann;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-18
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  66     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2009-04-08     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-8     Citation Subset:  IM    
Affiliation:
INSERM U780, 16 avenue Paul-Vaillant Couturier, Villejuif Cedex, France. estelle.rage@inserm.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollutants / toxicity
Air Pollution / adverse effects*,  statistics & numerical data
Air Pollution, Indoor / adverse effects,  statistics & numerical data
Asthma / etiology*,  physiopathology
Environmental Monitoring / methods
Female
Humans
Lung / physiopathology
Male
Middle Aged
Nitrogen Dioxide / toxicity
Odds Ratio
Ozone / toxicity
Prospective Studies
Residence Characteristics
Risk
Seasons
Severity of Illness Index
Sulfur Dioxide / toxicity
Chemical
Reg. No./Substance:
0/Air Pollutants; 10028-15-6/Ozone; 10102-44-0/Nitrogen Dioxide; 7446-09-5/Sulfur Dioxide
Investigator
Investigator/Affiliation:
F Kauffmann / ; I Pin / ; M Korobaeff / ; F Neukirch / ; I Annesi-Maesano / ; F Kauffmann / ; N Le Moual / ; R Nadif / ; M P Oryszczyn / ; V Siroux / ; J Feingold / ; M H Dizier / ; E Bouzigon / ; F Demenais / ; I Gut / ; M Lathrop / ; I Pin / ; C Pison / ; D Ecochard / ; F Gormand / ; Y Pacheco / ; D Charpin / ; D Vervloet / ; J Bousquet / ; A Lockhart / ; R Matran / ; E Paty / ; P Scheinmann / ; A Grimfeld / ; J Just / ; J Hochez / ; N Le Moual / ; C Ravault / ; N Chateigner / ; J Ferran /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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