Document Detail

Air pollution and allergy.
MedLine Citation:
PMID:  10780792     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have found a recent increase in the prevalence of allergic diseases, especially in industrialized countries. A change in environmental factors may be considered as one of the causes of this increase. It has been reported that the prevalence of allergic diseases is higher in polluted areas than in unpolluted ones. Therefore, we focused on the effect of one air pollutant, suspended particulate matter (SPM), on allergic responses. We showed that SPM had an enhancing effect on the IgE antibody production in mice. In Japan, the number of cars with diesel engines has increased rapidly, and it has been calculated that 35-80% of SPM in large cities consists of diesel exhaust particulates (DEP). We demonstrated that DEP had an adjuvant effect on the IgE antibody production in mice when administered intraperitoneally or intranasally. In humans, it has been shown that nasal challenge with DEP enhanced total IgE and specific IgE production in nasal lavages. Furthermore, it has been demonstrated that DEP had an enhancing effect on Th2-type cytokine synthesis in both mice and humans. It cannot be excluded that DEP may be related to the increase in prevalence of allergic diseases through the effect on the IgE antibody production and Th2-cytokine synthesis.
S Takafuji; T Nakagawa
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  10     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-06-26     Completed Date:  2000-06-26     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM; X    
Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki-city, Kanagawa, Japan.
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MeSH Terms
Air Pollutants / adverse effects,  immunology*
Air Pollution / adverse effects*
Cytokines / biosynthesis
Gasoline / adverse effects
Hypersensitivity / epidemiology,  etiology,  immunology*
Immunoglobulin E / biosynthesis
Japan / epidemiology
Th2 Cells / immunology
Vehicle Emissions / adverse effects
Reg. No./Substance:
0/Air Pollutants; 0/Cytokines; 0/Gasoline; 0/Vehicle Emissions; 37341-29-0/Immunoglobulin E

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