Document Detail


Air pollutant effects on fetal and early postnatal development.
MedLine Citation:
PMID:  17963272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerical research on the health effects of air pollution has been published in the last decade. Epidemiological studies have shown that children's exposure to air pollutants during fetal development and early postnatal life is associated with many types of health problems including abnormal development (low birth weight [LBW], very low birth weight [VLBW], preterm birth [PTB], intrauterine growth restriction [IUGR], congenital defects, and intrauterine and infant mortality), decreased lung growth, increased rates of respiratory tract infections, childhood asthma, behavioral problems, and neurocognitive decrements. This review focuses on the health effects of major outdoor air pollutants including particulates, carbon monoxide (CO), sulfur and nitrogen oxides (SO(2), NOx), ozone, and one common indoor air pollutant, environmental tobacco smoke (ETS). Animal data is presented that demonstrate perinatal windows of susceptibility to sidestream smoke, a surrogate for ETS, resulting in altered airway sensitivity and cell type frequency. A study of neonatal monkeys exposed to sidestream smoke during the perinatal period and/or early postnatal period that resulted in an altered balance of Th1-/Th2-cytokine secretion, skewing the immune response toward the allergy-associated Th2 cytokine phenotype, is also discussed.
Authors:
Lei Wang; Kent E Pinkerton
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Birth defects research. Part C, Embryo today : reviews     Volume:  81     ISSN:  1542-975X     ISO Abbreviation:  Birth Defects Res. C Embryo Today     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-12-13     Revised Date:  2012-07-12    
Medline Journal Info:
Nlm Unique ID:  101167665     Medline TA:  Birth Defects Res C Embryo Today     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-54     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Center for Health and the Environment, University of California-Davis, Old Davis Road, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / adverse effects*
Air Pollution / adverse effects*
Air Pollution, Indoor / adverse effects
Allergens / adverse effects
Animals
Carbon Monoxide / adverse effects
Child
Child Development / drug effects*
Congenital Abnormalities / epidemiology,  etiology
Humans
Hypersensitivity / epidemiology,  immunology
Infant
Nitrogen Dioxide / adverse effects
Ozone / adverse effects
Respiratory Tract Diseases / epidemiology,  etiology,  immunology
Sudden Infant Death / etiology
Sulfur Dioxide / adverse effects
Tobacco Smoke Pollution / adverse effects
Grant Support
ID/Acronym/Agency:
ES 05707/ES/NIEHS NIH HHS; R01 ES 011634/ES/NIEHS NIH HHS; RR 00169/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Allergens; 0/Tobacco Smoke Pollution; 10028-15-6/Ozone; 10102-44-0/Nitrogen Dioxide; 630-08-0/Carbon Monoxide; 7446-09-5/Sulfur Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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