| Air-leak management after upper lobectomy in patients with fused fissure and chronic obstructive pulmonary disease: a pilot trial comparing sealant and standard treatment. | |
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MedLine Citation:
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PMID: 19776082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pilot trial to compare the efficacy of two different procedures to prevent postoperative air-leak in chronic obstructive pulmonary disease (COPD) patients submitted to upper lobectomy for non-small cell lung cancer. Sixty patients with COPD and lung cancer at the upper pulmonary lobes eligible for lobectomy were enrolled and randomly assigned either to standard treatment (ST) with stapling device or to electrocautery dissection and application of a collagen patch coated with human fibrinogen and thrombin (TachoSil) (experimental treatment [ET]) for the intra-operative completion of their fused fissures. Thirty patients were enrolled in each group during a three-year period. Preoperative characteristics were similar between the two groups. Statistically significant reduction of air-leak was registered in the ET group when overall incidence of postoperative air-leak (55% vs. 96%; P=0.03), postoperative air-leak (mean 1.63+/-1.96 vs. 4.33+/-4.12 days; P=0.0018), chest-drain (mean 3.53+/-1.59 vs. 5.90+/-3.72 days; P=0.0021) and hospital stay duration (mean 5.87+/-1.07 vs. 7.50+/-3.20 days; P=0.01) were considered. The use of TachoSil to prevent postoperative air-leak after interlobar fissure completion in patients with COPD submitted to upper lobectomy seems to be safe and more effective than the ST based on stapling device application. |
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Authors:
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Ottavio Rena; Esther Papalia; Tommaso Claudio Mineo; Fabio Massera; Emanuele Pirondini; Davide Turello; Caterina Casadio |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2009-09-23 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 9 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 973-7 Citation Subset: IM |
Affiliation:
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Thoracic Surgery Unit, University of Eastern Piedmont A. Avogadro, Via Frasconi, 14, 28100 Novara, Italy. ottaviorena@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Non-Small-Cell Lung / complications, surgery* Combined Modality Therapy Drainage Drug Combinations Electrocoagulation* Female Fibrinogen / therapeutic use* Humans Length of Stay Lung Neoplasms / complications, surgery* Male Middle Aged Pilot Projects Pneumonectomy / adverse effects* Postoperative Complications / prevention & control* Prospective Studies Pulmonary Disease, Chronic Obstructive / complications* Surgical Stapling* Thrombin / therapeutic use* Tissue Adhesives / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/TachoSil; 0/Tissue Adhesives; 9001-32-5/Fibrinogen; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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