Document Detail

Air Pollution and Non-Malignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project.
MedLine Citation:
PMID:  24521254     Owner:  NLM     Status:  Publisher    
Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and non-malignant respiratory mortality in 16 cohorts with individual level data within the multi center European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases, following a standardized procedure within ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using meta-analyses. Main Results: We found no significant associations between air pollution exposure and non-malignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts there was no association between air pollution exposure and non malignant respiratory mortality.
Konstantina Dimakopoulou; Evangelia Samoli; Rob Beelen; Massimo Stafoggia; Zorana Jovanovic Andersen; Barbara Hoffmann; Paul Fischer; Mark Nieuwenhuijsen; Paolo Vineis; Wei Xun; Gerard Hoek; Ole Raaschou-Nielsen; Anna Oudin; Bertil Forsberg; Lars Modig; Pekka Jousilahti; Timo Lanki; Anu Turunen; Bente Oftedal; Per Nafstad; Per E Schwarze; Johanna Penell; Laura Fratiglioni; Niklas Andersson; Nancy Pedersen; Michal Korek; Ulf De Faire; Kirsten Thorup Eriksen; Anne Tjønneland; Thomas Becker; Meng Wang; Bas Bueno-de-Mesquita; Ming-Yi Tsai; Marloes Eeftens; Petra H Peeters; Kees Meliefste; Alessandro Marcon; Ursula Krämer; Thomas Aj Kuhlbusch; Mohammad Vossoughi; Timothy Key; Kees de Hoogh; Regina Hampel; Annette Peters; Joachim Heinrich; Gudrun Weinmayr; Hans Concin; Gabriele Nagel; Alex Ineichen; Bénédicte Jacquemin; Morgane Stempfelet; Alice Vilier; Fulvio Ricceri; Carlotta Sacerdote; Xanthi Pedeli; Michalis Katsoulis; Antonia Trichopoulou; Bert Brunekreef; Klea Katsouyanni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-12
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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