| Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. | |
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MedLine Citation:
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PMID: 22237295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies suggest that air pollution is related to thrombosis, inflammation, and endothelial dysfunction. Mechanisms and sources of susceptibility are still unclear. One possibility is that these associations can be modified by DNA methylation states. METHODS: We conducted a cohort study with repeated measurements of fibrinogen, C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in 704 elderly men participating in the Veterans Administration Normative Aging Study (2000-2009). We investigated short- and intermediate-term air pollution effects on these blood markers, and epigene-environment interactions by DNA methylation of Alu, LINE-1, tissue factor (F3), Toll-like receptor 2 (TLR-2), and ICAM-1. RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Ozone was a predictor of C-reactive protein and ICAM-1. Particle number, black carbon, NO(2), CO, PM(2.5), and sulfates were associated with ICAM-1 and VCAM-1. An interquartile range increase in 24-hour exposure for NO(2) was associated with a 1.7% (95% confidence interval = 0.2%-3.3%) increase in fibrinogen for ozone; a 10.8% (2.2%-20.0%) increase in C-reactive protein for particle number; a 5.9% (3.6%-8.3%) increase in ICAM-1; and for PM(2.5), a 3.7% (1.7%-5.8%) increase in VCAM-1. The air pollution effect was stronger among subjects having higher Alu, lower LINE-1, tissue factor, or TLR-2 methylation status. CONCLUSION: We observed associations of traffic-related pollutants on fibrinogen, and both traffic and secondary particles on C-reactive protein, ICAM-1, and VCAM-1. There was effect modification by DNA methylation status, indicating that epigenetic states can convey susceptibility to air pollution. |
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Authors:
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Marie-Abele Bind; Andrea Baccarelli; Antonella Zanobetti; Letizia Tarantini; Helen Suh; Pantel Vokonas; Joel Schwartz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 23 ISSN: 1531-5487 ISO Abbreviation: Epidemiology Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-09 Completed Date: 2012-05-25 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 332-40 Citation Subset: IM |
Affiliation:
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Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. mbind@hsph.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Air Pollution / adverse effects* Biological Markers / blood Blood Coagulation Disorders / blood, chemically induced*, genetics C-Reactive Protein / analysis Carbon / adverse effects Carbon Monoxide / adverse effects DNA Methylation / drug effects Endothelium, Vascular / drug effects*, physiopathology Epigenesis, Genetic* Fibrinogen / analysis Gene-Environment Interaction Humans Inflammation / blood, chemically induced*, genetics Intercellular Adhesion Molecule-1 / blood Male Nitrogen Dioxide / adverse effects Ozone / adverse effects Particulate Matter / adverse effects Prospective Studies Vascular Cell Adhesion Molecule-1 / blood Vascular Diseases / blood, chemically induced*, genetics |
| Grant Support | |
ID/Acronym/Agency:
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2R01-ES015172/ES/NIEHS NIH HHS; ES00002/ES/NIEHS NIH HHS; ES014663/ES/NIEHS NIH HHS; P01_ES008925/ES/NIEHS NIH HHS; P30 ES000002/ES/NIEHS NIH HHS; R01 ES015172-02/ES/NIEHS NIH HHS; R01-ES015172/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Particulate Matter; 0/Vascular Cell Adhesion Molecule-1; 10028-15-6/Ozone; 10102-44-0/Nitrogen Dioxide; 126547-89-5/Intercellular Adhesion Molecule-1; 630-08-0/Carbon Monoxide; 7440-44-0/Carbon; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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