Document Detail

Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts.
MedLine Citation:
PMID:  25036432     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Accumulating evidence from laboratory animal and human studies suggests that air pollution exposure during pregnancy affects cognitive and psychomotor development in childhood.
METHODS:: We analyzed data from 6 European population-based birth cohorts-GENERATION R (The Netherlands), DUISBURG (Germany), EDEN (France), GASPII (Italy), RHEA (Greece), and INMA (Spain)-that recruited mother-infant pairs from 1997 to 2008. Air pollution levels-nitrogen oxides (NO2, NOx) in all regions and particulate matter (PM) with diameters of <2.5, <10, and 2.5-10 μm (PM2.5, PM10, and PMcoarse, respectively) and PM2.5 absorbance in a subgroup-at birth addresses were estimated by land-use regression models, based on monitoring campaigns performed primarily between 2008 and 2011. Levels were back-extrapolated to exact pregnancy periods using background monitoring sites. Cognitive and psychomotor development was assessed between 1 and 6 years of age. Adjusted region-specific effect estimates were combined using random-effects meta-analysis.
RESULTS:: A total of 9482 children were included. Air pollution exposure during pregnancy, particularly NO2, was associated with reduced psychomotor development (global psychomotor development score decreased by 0.68 points [95% confidence interval = -1.25 to -0.11] per increase of 10 μg/m in NO2). Similar trends were observed in most regions. No associations were found between any air pollutant and cognitive development.
CONCLUSIONS:: Air pollution exposure during pregnancy, particularly NO2 (for which motorized traffic is a major source), was associated with delayed psychomotor development during childhood. Due to the widespread nature of air pollution exposure, the public health impact of the small changes observed at an individual level could be considerable.
Mònica Guxens; Raquel Garcia-Esteban; Lise Giorgis-Allemand; Joan Forns; Chiara Badaloni; Ferran Ballester; Rob Beelen; Giulia Cesaroni; Leda Chatzi; Maria de Agostini; Audrey de Nazelle; Marloes Eeftens; Mariana F Fernandez; Ana Fernández-Somoano; Francesco Forastiere; Ulrike Gehring; Akhgar Ghassabian; Barbara Heude; Vincent W V Jaddoe; Claudia Klümper; Manolis Kogevinas; Ursula Krämer; Béatrice Larroque; Aitana Lertxundi; Nerea Lertxuni; Mario Murcia; Vladislav Navel; Mark Nieuwenhuijsen; Daniela Porta; Rosa Ramos; Theano Roumeliotaki; Rémy Slama; Mette Sørensen; Euripides G Stephanou; Dorothea Sugiri; Adonina Tardón; Henning Tiemeier; Carla M T Tiesler; Frank C Verhulst; Tanja Vrijkotte; Michael Wilhelm; Bert Brunekreef; Göran Pershagen; Jordi Sunyer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-16
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  -     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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