Document Detail

Air-conducted oVEMPs provide the best separation between intact and superior canal dehiscent labyrinths.
MedLine Citation:
PMID:  23151775     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: First, to define the best single-step suprathreshold screening test for superior canal dehiscence syndrome (SCDS); second, to obtain further insight into the relative sensitivity of vestibular afferents to sound vibration in the presence of a superior canal dehiscence.
STUDY DESIGN: Prospective study.
SETTING: Tertiary referral center.
PATIENTS: Eleven patients with surgically confirmed SCDS (mean, 50 yr; range, 32-66 yr) and 11 age-matched, healthy subjects (right ear only) with no hearing or vestibular deficits (mean, 50 yr; range, 33-66 yr).
INTERVENTION: All subjects completed ocular and cervical vestibular evoked myogenic potential (o- and cVEMP) testing in response to air conduction (click and 500 Hz tone burst) and midline bone conduction (reflex hammer and Mini-shaker) stimulation.
MAIN OUTCOME MEASURES: OVEMP n10 amplitude and cVEMP corrected peak-to-peak amplitude.
RESULTS: OVEMP n10 amplitudes were significantly higher in SCDS when compared with healthy controls in response to all stimuli with the exception of reflex hammer. Likewise, cVEMP-corrected peak-to-peak amplitudes were significantly higher in SCDS when compared with healthy controls for air conduction stimulation (click and 500 Hz toneburst). However, there were no significant differences between groups for midline taps (reflex hammer or mini-shaker). Receiver operating characteristic curves demonstrated that oVEMPs in response to air conduction stimulation provided the best separation between SCDS and healthy controls.
CONCLUSION: OVEMPs in response to air conduction stimulation (click and 500 Hz toneburst) provide the best separation between SCDS and healthy controls and are therefore the best single-step screening test for SCDS.
Kristen L Janky; Kimanh D Nguyen; Miriam Welgampola; M Geraldine Zuniga; John P Carey
Related Documents :
22394795 - 73 application of quantum dot conjugates for investigating mammalian spermatozoa.
22462365 - Space shuttle flight crew spatial orientation survey results.
10520165 - Temporal and spatial rhythmicity of jejunal wall motion in rats.
17098275 - Treated amblyopes remain deficient in spatial vision: a contrast sensitivity and extern...
2307775 - Inner hair cell responses to the 2f1-f2 intermodulation distortion product.
21084195 - Identifying gait events without a force plate during running: a comparison of methods.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  34     ISSN:  1537-4505     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-05-24     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acoustic Stimulation
Ear Diseases / diagnosis*,  physiopathology
Ear, Inner / physiopathology*
Middle Aged
Prospective Studies
Semicircular Canals / physiopathology
Vestibular Diseases / diagnosis*,  physiopathology
Vestibular Evoked Myogenic Potentials / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Is it time to shift to better characterization of patients in trials assessing novel antidepressants...
Next Document:  Developmental effects of family environment on outcomes in pediatric cochlear implant recipients.