Document Detail


Air-conducted oVEMPs provide the best separation between intact and superior canal dehiscent labyrinths.
MedLine Citation:
PMID:  23151775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: First, to define the best single-step suprathreshold screening test for superior canal dehiscence syndrome (SCDS); second, to obtain further insight into the relative sensitivity of vestibular afferents to sound vibration in the presence of a superior canal dehiscence.
STUDY DESIGN: Prospective study.
SETTING: Tertiary referral center.
PATIENTS: Eleven patients with surgically confirmed SCDS (mean, 50 yr; range, 32-66 yr) and 11 age-matched, healthy subjects (right ear only) with no hearing or vestibular deficits (mean, 50 yr; range, 33-66 yr).
INTERVENTION: All subjects completed ocular and cervical vestibular evoked myogenic potential (o- and cVEMP) testing in response to air conduction (click and 500 Hz tone burst) and midline bone conduction (reflex hammer and Mini-shaker) stimulation.
MAIN OUTCOME MEASURES: OVEMP n10 amplitude and cVEMP corrected peak-to-peak amplitude.
RESULTS: OVEMP n10 amplitudes were significantly higher in SCDS when compared with healthy controls in response to all stimuli with the exception of reflex hammer. Likewise, cVEMP-corrected peak-to-peak amplitudes were significantly higher in SCDS when compared with healthy controls for air conduction stimulation (click and 500 Hz toneburst). However, there were no significant differences between groups for midline taps (reflex hammer or mini-shaker). Receiver operating characteristic curves demonstrated that oVEMPs in response to air conduction stimulation provided the best separation between SCDS and healthy controls.
CONCLUSION: OVEMPs in response to air conduction stimulation (click and 500 Hz toneburst) provide the best separation between SCDS and healthy controls and are therefore the best single-step screening test for SCDS.
Authors:
Kristen L Janky; Kimanh D Nguyen; Miriam Welgampola; M Geraldine Zuniga; John P Carey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  34     ISSN:  1537-4505     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-05-24     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Aged
Ear Diseases / diagnosis*,  physiopathology
Ear, Inner / physiopathology*
Electromyography
Female
Humans
Male
Middle Aged
Prospective Studies
Semicircular Canals / physiopathology
Vestibular Diseases / diagnosis*,  physiopathology
Vestibular Evoked Myogenic Potentials / physiology*
Grant Support
ID/Acronym/Agency:
NIH/NIDCD R01 DC005040//PHS HHS; R01 DC005040/DC/NIDCD NIH HHS; T32DC000023/DC/NIDCD NIH HHS
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