| Aided visual inspection with acetic acid (VIA) and HPV detection as optional screening tools for cervical cancer and its precursor lesions. | |
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MedLine Citation:
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PMID: 16440819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF INVESTIGATION: To assess the contribution of visual inspection with acetic acid (VIA) and Hybrid Capture II (HCII) as adjunct methods to the Pap test in detecting cervical neoplasia. SUBJECTS AND METHODS: This was a cross-sectional study with 809 women who consecutively attended gynecological consultations at Campinas University, Brazil, from January 2002 to July 2003. Pap test, HCII, VIA, and colposcopy were offered to all patients. Performance of tests (alone or in combination) in detecting histologically confirmed lesions was evaluated. RESULTS: Of the 40 patients with CIN, 69% had CIN1, 26% CIN2 or CIN3 and one patient had invasive carcinoma. VIA had the best performance in detecting CIN, yielding 72% sensitivity and 91% specificity. Considering only CIN2 or worse as significant lesions, HCII had the best sensitivity (73%), while the Pap test was the most specific (93%). Combining the three exams, 92% of the CIN1 or worse were detected. When CIN1 was excluded from the analysis, Pap smear plus HCII delivered 82% sensitivity and 79% specificity. However, this combination yielded a very low (5%) PPV. CONCLUSION: VIA and HCII contributed to the screening of cervical neoplasia in a group of Brazilian women, but the cost-effectiveness of conjoint screening modalities is still debatable. |
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Authors:
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J F Bragança; S F Derchain; L O Sarian; S M Messias da Silva; S Labatte; L C Zeferino |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental obstetrics & gynecology Volume: 32 ISSN: 0390-6663 ISO Abbreviation: Clin Exp Obstet Gynecol Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-30 Completed Date: 2006-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802110 Medline TA: Clin Exp Obstet Gynecol Country: Italy |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology Department, Universidade Estadual de Campinas State University, Campinas, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid
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diagnostic use* Adolescent Adult Biopsy Cervical Intraepithelial Neoplasia / diagnosis* Cervix Uteri / pathology, virology Colposcopy Cross-Sectional Studies DNA Probes, HPV Female Humans Middle Aged Neoplasm Staging Papillomaviridae* Papillomavirus Infections / diagnosis* Physical Examination / methods* Prospective Studies Sensitivity and Specificity Uterine Cervical Neoplasms / diagnosis* Vaginal Smears |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes, HPV; 64-19-7/Acetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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