| Ah receptor and NF-kappaB interplay on the stage of epigenome. | |
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MedLine Citation:
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PMID: 19014911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the basic helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) family. Its ligands include many natural and synthetic compounds, some of which, such as polyhalogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, are important environmental contaminants. NF-kappaB is a pleiotropic factor that regulates many physiological and pathophysiological processes including the immune and inflammatory responses. In the past decade, accumulating evidence suggests close interactions between AhR and NF-kappaB pathways, and these interactions are potentially important mechanisms for many pathological processes such as the chemical-induced immune dysfunctions, carcinogenesis and alteration of xenobiotic metabolism and disposition. AhR-NF-kappaB interaction has become a mechanistic linchpin linking certain pathological responses induced by environmental insults. Furthermore, the AhR-NF-kappaB interaction provides basis for therapeutic applications of certain AhR ligands to treat human diseases. The effects of AhR-NF-kappaB on the epigenome are an important area that is not well understood. In this review, I highlight current research regarding the AhR-NF-kappaB(RelA) interactions with emphasis on the epigenetic impacts of these interactions on chromatin modifications and transcription elongation control. |
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Authors:
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Yanan Tian |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-10-28 |
Journal Detail:
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Title: Biochemical pharmacology Volume: 77 ISSN: 1873-2968 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-03-06 Revised Date: 2009-05-21 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 670-80 Citation Subset: IM |
Affiliation:
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Interdisciplinary Graduate Program of Toxicology, Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843-4466, USA. ytian@cvm.tamu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin / genetics, metabolism Cytochrome P-450 CYP1A1 / genetics, metabolism Environmental Pollutants / toxicity Epigenesis, Genetic* Gene Expression Regulation / drug effects Humans NF-kappa B / genetics, physiology* Receptor Cross-Talk / physiology* Receptors, Aryl Hydrocarbon / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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ES09859/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Environmental Pollutants; 0/NF-kappa B; 0/Receptors, Aryl Hydrocarbon; EC 1.14.14.1/Cytochrome P-450 CYP1A1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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