| Agyria-pachygyria: clinical, neuroimaging, and neurophysiologic correlations. | |
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MedLine Citation:
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PMID: 12393126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Agyria-pachygyria complex is a disorder of neuronal migration and organization. Patients suffer either motor or intellectual retardation. We report our experiences of 10 patients with agyria-pachygyria complex and evaluate their clinical features, electroencephalography, and evoked potentials. Of nine electroencephalography examinations, five patients demonstrated characteristically high-amplitude fast activity. One of nine patients had an abnormal brainstem auditory-evoked potential. Three of seven patients had abnormal goggled visual-evoked potential. Six patients received somatosensory-evoked potential examinations, and five of these were abnormal, including four with prolonged central conduction times. Of the 10 patients, eight survived with variable intellectual and motor retardation; two died of sepsis. Patients with grades 1-4 agyria-pachygyria had high incidences of somatosensory-evoked potential abnormalities and also suffered worse neurologic outcomes. Normal brainstem auditory-evoked potential but abnormal cortical somatosensory-evoked potential components and prolonged central conduction time in these patients indicate that agyria-pachygyria is a supratentorial disease. We conclude that somatosensory-evoked potential examination is supplemental to neuroimaging in predicting the neurologic prognosis of patients with agyria-pachygyria. |
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Authors:
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Jao Shwann Liang; Wang Tso Lee; Chainllie Young; Steven Shinnforng Peng; Yu-Zen Shen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 27 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-23 Completed Date: 2003-01-23 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 171-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / abnormalities*, pathology, physiopathology Child Child, Preschool Electroencephalography* Epilepsy, Tonic-Clonic / congenital, diagnosis, physiopathology Female Humans Infant Magnetic Resonance Imaging* Male Mental Retardation / diagnosis, physiopathology Neural Conduction / physiology Neurologic Examination Neurons / physiology Prognosis Psychomotor Disorders / congenital, diagnosis, physiopathology Reaction Time / physiology Spasms, Infantile / congenital, diagnosis, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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