Document Detail

Agreement between predicted risk and prevalence of Down syndrome in first trimester nuchal translucency screening.
MedLine Citation:
PMID:  12378577     Owner:  NLM     Status:  MEDLINE    
The agreement between predicted risks of Down syndrome and observed prevalence was investigated in a population of 11,847 singleton pregnancies screened by first trimester nuchal translucency at a single institution. Twenty-seven cases of Down syndrome were observed; 20 were detected prenatally by nuchal translucency and maternal age screening, three by other means and four postnatally. The screened women were grouped according to their predicted risk of having an affected pregnancy, and this was compared with the observed prevalence. A significant correlation between predicted and observed prevalences was noted, thus demonstrating that risk estimates for Down syndrome based on first trimester nuchal translucency screening are accurate.
Federico Prefumo; Basky Thilaganathan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  22     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-14     Completed Date:  2002-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  917-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London, UK.
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MeSH Terms
Chorionic Villi Sampling
Down Syndrome / epidemiology*
Gestational Age*
Middle Aged
Neck / embryology*,  ultrasonography*
Pregnancy Trimester, First
Risk Factors
Ultrasonography, Prenatal*

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