Document Detail


Agreement between pQCT and DXA-derived indices of bone geometry, density and theoretical strength in females of varying age, maturity and physical activity.
MedLine Citation:
PMID:  21190309     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Measurement of bone mass, geometry, density and strength are critical in bone research and clinical studies. For pQCT, single and repeated measurements are particularly adversely affected by movement and positional variation. DXA-derived indices may alleviate these problems and provide useful alternative assessments. To evaluate this hypothesis, distal radius DXA and pQCT indices were compared in 101 healthy females aged 8.0 years to 22.8 years (pre-puberty to adulthood), reflecting a broad range of body sizes, physical maturity and activity exposures. At the diaphysis, correlations were rho= +0.77 to +0.98, with strong inter-method agreement for most indices. At the metaphysis, correlations were rho= +0.64 to +0.97; inter-method agreement improved with modifications to the simplified geometric formulae, more closely reflecting metaphyseal bone geometry. Further improvements may be possible, as skeletal size and maturity-related biases in agreement were detected. Overall, DXA-derived indices may provide a useful assessment of bone geometry, density and theoretical strength, contingent upon appropriate consideration of their limitations. © 2010 American Society for Bone and Mineral Research.
Authors:
J N Dowthwaite; P P E Flowers; T A Scerpella
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-28
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  -     ISSN:  1523-4681     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY.
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