Document Detail

Agraphia in intellectually normal Japanese patients with ALS: omission of kana letters.
MedLine Citation:
PMID:  19377859     Owner:  NLM     Status:  MEDLINE    
To investigate the occurrence of a writing defect, omission of kana letters (OKL), in intellectually normal Japanese patients with amyotrophic lateral sclerosis (ALS), and define the neuroimaging profile of OKL. Sixteen Japanese adults (10 men and 6 women), similar in age (mean 62.9 +/- 9.9 years) and level of education (mean 12.6 +/- 2.13 years), with early-stage, classical ALS (mean duration 15.9 +/- 5.45 months) were investigated, including tests of motor function and ALS progression; intellectual function including writing ability; and neuroimaging, with follow-up of 1 year. Main outcome measures were as follows: Raven's Colored Progressive Matrices (RCPM: intellect and psychomotor speed); one-minute verbal fluency measurement; paired associate word-learning test (PAWLT); Western Aphasia Battery (WAB); moraic segmentation test; magnetic resonance imaging (MRI); and (123)I-isopropyl amphetamine ((123)I-IMP) or (99m)Tc-ethylcysteinate dimmer (ECD) single photon emission tomography (SPECT). Three patients (18.8%) showed OKL (WAB), with disturbance in moraic segmentation. One patient showed decreased blood flow to the bilateral frontal lobes by (123)I-IMP-SPECT. Patients with OKL did not differ significantly from those without in the RCPM (intellect), RCPM (time), verbal fluency, or PAWLT (p = 0.10, 0.84, 0.63, 0.55). Although motor dysfunction and weakness progressed during follow-up, none developed symptoms of dementia. The OKL may develop as a relatively early cognitive symptom in intellectually normal Japanese patients with classical ALS. The neuroimaging profile of OKL remains uncertain.
Masayuki Satoh; Katsuhiko Takeda; Shigeki Kuzuhara
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Publication Detail:
Type:  Journal Article     Date:  2009-04-18
Journal Detail:
Title:  Journal of neurology     Volume:  256     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-27     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1455-60     Citation Subset:  IM    
Mie St Cross Hospital, Komono, Mie 510-1232, Japan.
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MeSH Terms
Agraphia / etiology*,  radionuclide imaging
Amyotrophic Lateral Sclerosis / complications*,  radionuclide imaging
Brain / blood supply,  radionuclide imaging
Disease Progression
Follow-Up Studies
Iodine Radioisotopes
Middle Aged
Neuropsychological Tests
Severity of Illness Index
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Iodine Radioisotopes

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