| Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis. | |
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MedLine Citation:
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PMID: 8610477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Agranulocytosis and septicaemia developing in a patient with rheumatoid arthritis after 3 years' intermittent treatment with diclofenac, cimetidine and flucloxacillin for staphylococcal osteomyelitis is described. Treatment with recombinant granulocyte-colony-stimulating factor and high-dose methylprednisolone had no effect on the neutropenia which resolved on stopping all drug therapy. Relapse of agranulocytosis followed reintroduction of flucloxacillin and cimetidine 3 months later. |
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Authors:
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I E Burton; K M Moussa; P A Sanders |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta haematologica Volume: 94 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1995 |
Date Detail:
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Created Date: 1996-05-24 Completed Date: 1996-05-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 196-8 Citation Subset: IM |
Affiliation:
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Department of Haematology, University Hospital of South Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Agranulocytosis / chemically induced*, drug therapy Arthritis, Rheumatoid / complications* Cimetidine / therapeutic use Female Floxacillin / adverse effects*, therapeutic use Fluorescent Antibody Technique, Indirect Granulocyte Colony-Stimulating Factor / therapeutic use Humans Kinetics Methylprednisolone / therapeutic use Osteomyelitis / complications, drug therapy, microbiology* Penicillins / therapeutic use* Recombinant Proteins / therapeutic use Staphylococcal Infections / complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Penicillins; 0/Recombinant Proteins; 143011-72-7/Granulocyte Colony-Stimulating Factor; 51481-61-9/Cimetidine; 5250-39-5/Floxacillin; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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