Document Detail

Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis.
MedLine Citation:
PMID:  8610477     Owner:  NLM     Status:  MEDLINE    
Agranulocytosis and septicaemia developing in a patient with rheumatoid arthritis after 3 years' intermittent treatment with diclofenac, cimetidine and flucloxacillin for staphylococcal osteomyelitis is described. Treatment with recombinant granulocyte-colony-stimulating factor and high-dose methylprednisolone had no effect on the neutropenia which resolved on stopping all drug therapy. Relapse of agranulocytosis followed reintroduction of flucloxacillin and cimetidine 3 months later.
I E Burton; K M Moussa; P A Sanders
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  94     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1995  
Date Detail:
Created Date:  1996-05-24     Completed Date:  1996-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  196-8     Citation Subset:  IM    
Department of Haematology, University Hospital of South Manchester, UK.
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MeSH Terms
Agranulocytosis / chemically induced*,  drug therapy
Arthritis, Rheumatoid / complications*
Cimetidine / therapeutic use
Floxacillin / adverse effects*,  therapeutic use
Fluorescent Antibody Technique, Indirect
Granulocyte Colony-Stimulating Factor / therapeutic use
Methylprednisolone / therapeutic use
Osteomyelitis / complications,  drug therapy,  microbiology*
Penicillins / therapeutic use*
Recombinant Proteins / therapeutic use
Staphylococcal Infections / complications,  drug therapy*
Reg. No./Substance:
0/Penicillins; 0/Recombinant Proteins; 143011-72-7/Granulocyte Colony-Stimulating Factor; 51481-61-9/Cimetidine; 5250-39-5/Floxacillin; 83-43-2/Methylprednisolone

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