| Agonist replacement therapy for cocaine dependence: a translational review. | |
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MedLine Citation:
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PMID: 22300101 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Cocaine use disorders are prevalent throughout the world. Agonist replacement therapy is among the most effective strategies for managing substance use disorders including nicotine and opioid dependence. This paper reviews the translational literature, including preclinical experiments, human laboratory studies and clinical trials, to determine whether agonist-replacement therapy is a viable strategy for managing cocaine dependence. Discussion is limited to transporter blockers (i.e., methylphenidate) and releasers (i.e., amphetamine analogs) that are available for use in humans in the hope of impacting clinical research and practice more quickly. The translational review suggests that agonist-replacement therapy, especially monoamine releasers, may be effective for managing cocaine dependence. Future directions for medications development are also discussed because the viability of agonist-replacement therapy for cocaine dependence may hinge on identifying novel compounds or formulations that have less abuse and diversion potential. |
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Authors:
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Craig R Rush; William W Stoops |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Future medicinal chemistry Volume: 4 ISSN: 1756-8927 ISO Abbreviation: Future Med Chem Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101511162 Medline TA: Future Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 245-65 Citation Subset: IM |
Affiliation:
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Department of Behavioral Science, University of Kentucky, College of Medicine, Medical Behavioral Science Building, Lexington, KY 40536-0086, USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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