Document Detail

Agomelatine and sertraline for the treatment of depression in type 2 diabetes mellitus.
MedLine Citation:
PMID:  23409693     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The present study compared the efficacy of agomelatine and sertraline in the treatment of symptoms of depression/anxiety, diabetes self-care and metabolic control in a sample of depressed patients with non-optimally controlled type 2 diabetes mellitus (DM).
METHOD: This was an observational open label study of 40 depressed patients with DM who were randomly assigned to receive either agomelatine or sertraline, and were assessed over a 4-month period for depression, anxiety, self-care, fasting plasma glucose, haemoglobin A1c and body weight.
RESULTS: Lower anxiety and depression scores as well as higher self-care scores were measured in the agomelatine group compared with the sertraline group after 4 months of treatment. Although the main effects of treatment on final body weight and fasting plasma glucose were not significant, significantly lower final haemoglobin A1c levels were measured in the agomelatine group compared with the sertraline group. Both antidepressants were well tolerated and none of the patients dropped-out of the study.
CONCLUSION: The main finding of the present small pilot study was that agomelatine may be a promising agent in the treatment of symptoms of depression and anxiety as well as in the improvement of health-related behaviours, in depressed patients with type 2 DM possibly offering some advantages over sertraline. However, the lack of a placebo control group limits the generalisability of the findings and warrants further studies.
D Karaiskos; E Tzavellas; I Ilias; I Liappas; T Paparrigopoulos
Related Documents :
24733793 - Screening, assessment, and care of anxiety and depressive symptoms in adults with cance...
24345733 - Sleep duration, but not insomnia, predicts the 2-year course of depressive and anxiety ...
21796893 - Type d or 'distressed' personality in sarcoidosis and idiopathic pulmonary fibrosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  67     ISSN:  1742-1241     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Athens University Medical School, 1st Department of Psychiatry, Eginition Hospital, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute confusional migraine: is it a distinct form of migraine?
Next Document:  Dupuytren's disease presentation, referral pathways and resource utilisation in Europe: regional ana...