| Agnogenic myeloid metaplasia (AMM)--correlation of bone marrow lesions with laboratory data: a longitudinal clinicopathological study on 114 patients. | |
| | |
MedLine Citation:
|
PMID: 2767619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A clinicopathological study was performed on 114 patients (46 male/68 female, median age 67 years) with the diagnosis of agnogenic myeloid metaplasia (AMM) respectively primary osteo-myelofibrosis which was not preceded by any other or allied subtype of chronic myeloproliferative disorders. On admission patients revealed a striking variability of laboratory data as well as different histopathological features of initial bone marrow biopsies. For this reason discrimination was done into two groups based on bone marrow findings: group I patients (n = 46, 19 male/27 female) showed a hypercellular marrow without or only borderline (n = 24) to slight (n = 22) reticulin fibrosis and group II cases (n = 68, 27 male/41 female) displayed coarse bundles of collagen fibres (n = 18) frequently accompanied by osteosclerosis (n = 50). Statistical analysis of the corresponding initial hematological findings resulted in significant differences. These differences concerned also the complications occurring during the lengthy course of disease, which included a higher incidence of pancytopenia and severe marrow failure with hemorrhage and blast crisis in group II patients. However, overall survival time was not different in both groups. This may be related to the similarity of age distribution (64 resp. 65 years) and its significant association with arteriosclerotic vascular lesions. Consequently acute myocardial infarction and congestive heart failure were frequent causes of death in addition to infections due to marrow failure and blast crisis. Repeated bone marrow biopsies in 24 patients revealed an insidious transition from hypercellular lesions (group I) into advanced fibro-osteosclerotic changes (group II) concurring with laboratory data. Therefore our discrimination into two groups of patients represents variable stages or static histological and corresponding hematologic features in the evolution of a dynamic disease process in AMM. |
| | |
Authors:
|
J Thiele; R Zankovich; T Steinberg; R Fischer; V Diehl |
Related Documents
:
|
2147599 - Regulation of calcium-parathyroid hormone feedback in primary hyperparathyroidism: effe... 9292789 - Osteoclastogenesis in iliac bone marrow of patients with rheumatoid arthritis. 15993669 - Reduced bone mineral density in male severe acute respiratory syndrome (sars) patients ... 16584509 - Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs.... 21248669 - Cardiovascular risk and lupus disease. 4044209 - Calcitonin deficit syndrome in thyroidectomized patients. 12920629 - Longitudinal analysis of intermediate outcomes in adolescent hemodialysis patients. 21152919 - Takayasu arteritis: assessment of response to medical therapy based on clinical activit... 9371029 - Improved discriminative and evaluative capability of a refined version of skindex, a qu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hematological oncology Volume: 7 ISSN: 0278-0232 ISO Abbreviation: Hematol Oncol Publication Date: 1989 Sep-Oct |
Date Detail:
|
Created Date: 1989-10-05 Completed Date: 1989-10-05 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8307268 Medline TA: Hematol Oncol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 327-43 Citation Subset: IM |
Affiliation:
|
Institute of Pathology, University of Cologne, Federal Republic of Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Bone Marrow / pathology* Female Hematopoiesis Humans Leukocyte Count Longitudinal Studies Male Middle Aged Osteosclerosis / pathology Primary Myelofibrosis / metabolism, mortality, pathology*, therapy Spleen / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinico-pathological studies of cytochrome P-450 on human hepatic disorders
Next Document: A risk factor for relapse in Hodgkin's disease: female gender?