| Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. | |
| | |
MedLine Citation:
|
PMID: 22300747 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Agmatine, a polycationic amine synthesized via decarboxylation of l-arginine by arginine decarboxylase is reported to exhibit anti-hyperglycemic, antioxidant and memory enhancing effects. Therefore, we tested its influence against cognitive dysfunction in streptozotocin-induced diabetic rats using Morris water maze and object recognition paradigm. Lipid peroxidation and glutathione levels as parameters of oxidative stress and choline esterase (ChE) activity as a marker of cholinergic function were assessed in the cerebral cortex and hippocampus. Thirty days after diabetes induction rats showed a severe deficit in learning and memory associated with increased lipid peroxidation, decreased reduced glutathione, and elevated ChE activity. In contrast, chronic treatment with agmatine (5-10mg/kg, i.p. for 30days) improved cognitive performance, lowered hyperglycemia, oxidative stress, and ChE activity in diabetic rats. Further, memory improving effects of agmatine were independent of adrenal I(2) imidazoline receptors. In a separate set, agmatine treatment for an initial 15days after diabetes confirmation also significantly reduced memory impairment during training trials after 30days of diabetes confirmation. Moreover, treatment during training trials (30days after diabetes) also significantly reduced memory impairment in diabetic rats. In conclusion, the present study demonstrates that treatment with agmatine prevents changes in oxidative stress and ChE activity, and probably consequent memory impairment in diabetic rats. |
| | |
Authors:
|
Pravinkumar Bhutada; Yogita Mundhada; Vishwas Humane; Anand Rahigude; Prashant Deshmukh; Sandeep Latad; Kishor Jain |
Related Documents
:
|
22276937 - Involvement of nitrosative stress in experimental periodontitis in diabetic rats. 17461097 - Early diagnosis and treatment of celiac disease in type 1 diabetes. a longitudinal, cas... 12663567 - Type 2 diabetes in asian-indian urban children. 22577407 - Liver-protective effects of hydroalcoholic extract of allium hirtifolium boiss. in rats... 3800847 - Electrophysiological analysis of the sensitivity to calcium in ventricular muscle from ... 2981197 - Oxidative metabolism of neonatal and adult rabbit lung macrophages stimulated with opso... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
|
Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: - ISSN: 1878-4216 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Sinhgad College of Pharmacy, Post-Graduate Research Department, Off Sinhgad road, Vadgaon (Bk), Pune 41, Maharashtra, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies.
Next Document: Algorithm for the diagnosis and treatment of pediatric OSA: A proposal of two pediatric sleep center...